Synthesis, antioxidant, enzyme inhibition and DNA binding studies of novel N-benzylated derivatives of sulfonamide

被引：49

作者：

Abbas, Aadil ^{[1
]}

Murtaza, Shahzad ^{[2
]}

Tahir, Muhammad Nawaz ^{[3
]}

Shamim, Saima ^{[2
]}

Sirajuddin, Muhammad ^{[4
]}

Rana, Usman Ali ^{[5
]}

Naseem, Khadija ^{[2
]}

Rafique, Hummera ^{[2
]}

机构：

[1] Univ Punjab, Inst Chem, Lahore, Pakistan

[2] Univ Gujrat, Fac Sci, Dept Chem, Gujrat 50700, Pakistan

[3] Univ Sargodha, Dept Phys, Sargodha, Pakistan

[4] Univ Sci & Technol, Dept Chem, Bannu, Kpk, Pakistan

[5] King Saud Univ, Coll Engn, Sustainable Energy Technol Ctr, POB 800, Riyadh 11421, Saudi Arabia

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2016年 / 1117卷

关键词：

Sulfonamide; XRD; Antioxidant; DNA binding; Enzyme inhibition; Docking; ANTICANCER;

D O I：

10.1016/j.molstruc.2016.03.066

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A series of novel N-benzylated derivatives of sulfonamide were synthesized and characterized by FT-IR, NMR and XRD analysis. The synthesized compounds were assayed for their biological potential. The biological studies involved antioxidant, enzyme inhibition, and DNA interaction studies. Antioxidant potential was investigated by Ferric Reducing Antioxidant Power assay (FRAP) and DPPH free radical scavenging method, the capacity of synthesized compounds to inhibit the enzyme's activity was assayed by using the well-known Elman method whereas DNA interaction studies were carried out with the help UV Vis absorption titration method. Moreover, a direct correlation between enzyme inhibition activity and concentration of the compounds was observed both in experimental and molecular docking studies. DNA interaction studies of the synthesized compounds showed weak interaction. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：269 / 275

页数：7

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