Cobalt-Catalyzed Asymmetric Hydrogenation of 1,1-Diarylethenes

被引：118

作者：

Chen, Jianhui ^{[1
]}

Chen, Chenhui ^{[1
]}

Ji, Chonglei ^{[1
]}

Lu, Zhan ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 07期

基金：

中国国家自然科学基金;

关键词：

CROSS-COUPLING REACTIONS; ENANTIOSELECTIVE HYDROGENATION; ALKENE HYDROGENATION; 1,1-DISUBSTITUTED ALKENES; ARYL CHLORIDES; COMPLEXES; IRON; HYDROBORATION; LIGANDS; OLEFINS;

D O I：

10.1021/acs.orglett.6b00453

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly enantioselective cobalt-catalyzed hydrogenation of 1,1-diarylethenes was developed by using bench stable chiral oxazoline iminopyridine-cobalt complexes as precatalysts. A unique o-chloride effect was observed to achieve high enantioselectivity. Easy removal as well as further transformations of the chloro group make this protocol a potentially useful alternative to synthesize various chiral 1,1-diarylethanes. This process can be successfully performed under 1 atm of hydrogen at room temperature on gram scale.

引用

页码：1594 / 1597

页数：4

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