Androgen control of lipid metabolism in prostate cancer: novel insights and future applications

被引：96
作者：
Butler, Lisa M. [1 ]
Centenera, Margaret M. [1 ]
Swinnen, Johannes V. [2 ]
机构：
[1] Univ Adelaide, South Australian Hlth & Med Res Inst, Sch Med, Adelaide, SA, Australia
[2] KU Leuven Univ Leuven, LKI Leuven Canc Inst, Dept Oncol, Lab Lipid Metab & Canc, Leuven, Belgium
来源：
ENDOCRINE-RELATED CANCER | 2016年 / 23卷 / 05期
基金：
澳大利亚研究理事会;
关键词：
lipid metabolism; phospholipids; androgens; lipogenic enzymes; prostate cancer; lipidomics; FATTY-ACID SYNTHASE; PERIPROSTATIC ADIPOSE-TISSUE; DEPENDENT REGULATION; GENE-EXPRESSION; RECEPTOR; CELLS; LIPOGENESIS; ACTIVATION; PATHWAYS; SURVIVAL;
D O I：
10.1530/ERC-15-0556
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
One of the most typical hallmarks of prostate cancer cells is their exquisite dependence on androgens, which is the basis of the widely applied androgen deprivation therapy. Among the variety of key cellular processes and functions that are regulated by androgens, lipid metabolism stands out by its complex regulation and its many intricate links with cancer cell biology. Here, we review our current knowledge on the links between androgens and lipid metabolism in prostate cancer, and highlight recent developments and insights into the links between key oncogenic stimuli and altered lipid synthesis and/ or uptake that may hold significant potential for biomarker development and provide new vulnerabilities for therapeutic intervention.
引用
收藏
页码：R219 / R227
页数：9
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