Selective C-C Bond Cleavage of Cycloalkanones by NaNO2/HCl

被引：10
|
作者：
He, Tianyu [1 ]
Chen, Dengfeng [1 ]
Qian, Shencheng [1 ]
Zheng, Yu [1 ]
Huang, Shenlin [1 ]
机构：
[1] Nanjing Forestry Univ, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat F, Int Innovat Ctr Forest Chem & Mat, Coll Chem Engn, Nanjing 210037, Jiangsu, Peoples R China
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 16期
基金：
中国博士后科学基金;
关键词：
SODIUM-NITRITE; KETONES; ACTIVATION; OXIDATION;
D O I：
10.1021/acs.orglett.1c02327
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel selective fragmentation of cycloalkanones by NaNO2/HCl has been established. The C-C bond cleavage reaction proceeds smoothly under mild conditions, selectively affording versatile keto acids or oxime acids. The methodology can streamline the synthesis of valuable chiral molecules and isocoumarins from readily available feedstocks.
引用
收藏
页码：6525 / 6529
页数：5
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