Worrying yourself sick? Association between pre-eclampsia onset and health-related worry in pregnancy

被引:13
作者
Krishnamurti, Tamar [1 ]
Davis, Alexander L. [2 ]
Simhan, Hyagriv N. [3 ]
机构
[1] Univ Pittsburgh, Div Gen Internal Med, 200 Meyran Ave,Suite 200, Pittsburgh, PA 15213 USA
[2] Carnegie Mellon Univ, Dept Engn & Publ Policy, Pittsburgh, PA 15213 USA
[3] Univ Pittsburgh, Dept OBGYN & Reprod Sci, Pittsburgh, PA USA
基金
美国国家卫生研究院;
关键词
Pregnancy; Pre-eclampsia; Psychosocial stress; Worry; Machine learning; BIRTH; RISK;
D O I
10.1016/j.preghy.2019.09.003
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Psychosocial stress may influence pregnancy health. We examined the relationship between worry about pregnancy health and pre-eclampsia. General stress, mental health, and self-reported pregnancy health worry were measured in a study of 10,037 U.S. nulliparous women. Logistic regression found a dose-response relationship between first trimester pregnancy-health worry and subsequent pre-eclampsia onset, controlling for health history (Beta = 0.40, SE = 0.09, P < 1 x 10(-6)). A machine learning regularized regression found a significant relationship between worry and pre-eclampsia onset, controlling for all other potential predictors of pre-eclampsia measured at baseline, suggesting that worry plays a unique role in pre-eclampsia risk.
引用
收藏
页码:55 / 57
页数:3
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