IL-15 enhances CCR5-mediated migration of memory CD8+ T cells by upregulating CCR5 expression in the absence of TCR stimulation

被引：20

作者：

Seo, In-Ho ^{[1
]}

Eun, Hyuk Soo ^{[2
]}

Kim, Ja Kyung ^{[3
]}

Lee, Hoyoung ^{[1
]}

Jeong, Seongju ^{[1
]}

Choi, Seong Jin ^{[1
]}

Lee, Jeewon ^{[1
]}

Lee, Byung Seok ^{[2
]}

Kim, Seok Hyun ^{[2
]}

Rou, Woo Sun ^{[2
]}

Lee, Dong Hyeon ^{[4
]}

Kim, Won ^{[4
]}

Park, Su-Hyung ^{[1
]}

Shin, Eui-Cheol ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Daejeon 34141, South Korea

[2] Chungnam Natl Univ, Dept Internal Med, Sch Med, Daejeon 35015, South Korea

[3] Yonsei Univ, Yongin Severance Hosp, Dept Internal Med, Coll Med, Yongin 16995, South Korea

[4] Seoul Natl Univ, Seoul Metropolitan Govt, Dept Internal Med, Boramae Med Ctr,Coll Med, Seoul 07061, South Korea

来源：

CELL REPORTS | 2021年 / 36卷 / 04期

关键词：

INNATE-LIKE; PROLIFERATION; ANTIGEN; CHEMOKINES; EXPANSION; INDUCTION; SURVIVAL; EBV;

D O I：

10.1016/j.celrep.2021.109438

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During microbial infection, bystander CD8(+) T cells that are not specific to infecting pathogens can be activated by interleukin (IL)-15. However, the tissue-homing properties of bystander-activated CD8(+) T cells have not been elucidated. Here, we examine the effects of IL-15 on the expression of chemokine receptors on CD8(+) T cells and their migration. IL-15 upregulates CCR5 in memory CD8(+) T cells in the absence of T cell receptor (TCR) stimulation and enhances CCR5-dependent migration. IL-15-induced CCR5 upregulation is abrogated by TCR stimulation, indicating that CCR5 is upregulated in bystander-activated CD8(+) T cells. Moreover, CCR5 signals increase proliferation and cytotoxic protein expression in IL-15-treated memory CD8(+) T cells, although the increase has a small extent. CCR5 upregulation in bystander-activated CD8(+) T cells is associated with severe liver injury in patients with acute hepatitis A. Altogether, the results indicate that CCR5 upregulation by IL-15 mediates the migration of bystander-activated CD8(+) T cells.

引用

页数：15

共 27 条

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