The effects of N-terminal part modification of arginine vasopressin analogues with 2-aminoindane-2-carboxylic acid:: A highly potent V2 agonist

被引：16
|
作者：
Kowalczyk, Wioleta
Sobolewski, Dariusz
Prahl, Adam
Derdowska, Izabela
Borovickova, Lenka
Slaninova, Jirina
Lammek, Bernard
机构：
[1] Univ Gdansk, Fac Chem, PL-80952 Gdansk, Poland
[2] Acad Sci Czech Republ, Inst Organ Chem & Biochem, CR-16610 Prague, Czech Republic
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 50卷 / 12期
关键词：
D O I：
10.1021/jm070174s
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In this study we present the synthesis and some pharmacological properties of nine new analogues of arginine vasopressin modified in the N-terminal part of the molecule with 2-aminoindane-2-carboxylic acid (Aic). The peptides were tested for their in vitro uterotonic and in vivo pressor and antidiuretic activities. One of the new peptides, [Mpa(1),Aic(2),Val(4),D-Arg(8)]VP, exhibited an antidiuretic activity similar to that of [Mpa(1),D-Arg(8)]VP, thus being one of the most potent antidiuretic vasopressin analogues reported to date.
引用
收藏
页码：2926 / 2929
页数：4
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