The stability of intramolecular DNA quadruplexes with extended loops forming inter- and intra-loop duplexes

被引：24

作者：

Risitano, A ^{[1
]}

Fox, KR ^{[1
]}

机构：

[1] Univ Southampton, Div Biochem & Mol Biol, Sch Biol Sci, Southampton SO16 7PX, Hants, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2003年 / 1卷 / 11期

关键词：

D O I：

10.1039/b302251j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have examined the formation of intramolecular quadruplex DNA structures in which the loops have been extended so as to generate short DNA duplexes. Fluorescence melting and DNase I cleavage studies show that duplexes can be formed within each loop, but that duplexes between the loops are not stable.

引用

页码：1852 / 1855

页数：4

共 5 条

[1] Stability of intramolecular DNA quadruplexes: Comparison with DNA duplexes
Risitano, A
Fox, KR
BIOCHEMISTRY, 2003, 42 (21) : 6507 - 6513
[2] Influence of loop size on the stability of intramolecular DNA quadruplexes
Risitano, A
Fox, KR
NUCLEIC ACIDS RESEARCH, 2004, 32 (08) : 2598 - 2606
[3] A sequence-independent study of the influence of short loop lengths on the stability and topology of intramolecular DNA G-quadruplexes
Bugaut, Anthony
Balasubramanian, Shankar
BIOCHEMISTRY, 2008, 47 (02) : 689 - 697
[4] Topology conservation and loop flexibility in quadruplex-drug recognition: Crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes
Parkinson, Gary N.
Cuenca, Francisco
Neidle, Stephen
JOURNAL OF MOLECULAR BIOLOGY, 2008, 381 (05) : 1145 - 1156
[5] Thermodynamic Stability and Folding Kinetics of the Major G-Quadruplex and Its Loop Isomers Formed in the Nuclease Hypersensitive Element in the Human c-Myc Promoter: Effect of Loops and Flanking Segments on the Stability of Parallel-Stranded Intramolecular G-Quadruplexes
Hatzakis, Emmanuel
Okamoto, Keika
Yang, Danzhou
BIOCHEMISTRY, 2010, 49 (43) : 9152 - 9160

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