Propranolol enhances bone healing and implant osseointegration in rats tibiae

被引:37
作者
Al-Subaie, Ahmed E. [1 ,2 ,3 ]
Laurenti, Marco [1 ]
Abdallah, Mohamed-Nur [1 ]
Tamimi, Iskandar [1 ]
Yaghoubi, Farid [1 ]
Eimar, Hazem [1 ]
Makhoul, Nicholas [1 ,2 ]
Tamimi, Faleh [1 ]
机构
[1] McGill Univ, Fac Dent, Montreal, PQ H3A 0C7, Canada
[2] McGill Univ, Div Oral & Maxillofacial Surg, Montreal, PQ, Canada
[3] Univ Dammam, Coll Dent, Dammam, Saudi Arabia
基金
加拿大自然科学与工程研究理事会;
关键词
beta-blockers; bone healing; bone regeneration; osseointegration; propranolol; SYMPATHETIC-NERVOUS-SYSTEM; BETA-ADRENERGIC-RECEPTORS; OSTEOBLAST-LIKE CELLS; MORPHOGENETIC PROTEIN-2; PARATHYROID-HORMONE; TITANIUM IMPLANTS; TUMOR PROGRESSION; ANIMAL-MODELS; GROWTH-FACTOR; CANCER-CELLS;
D O I
10.1111/jcpe.12632
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Background: Propranolol, a non-selective beta-blocker widely used to treat cardiovascular conditions, favours bone accrual. Accordingly, we hypothesized that propranolol could be useful for improving bone healing and osseointegration. This in vivo study was designed to investigate the effect of propranolol on bone healing and osseointegration in rats' tibiae. Methods: On 24 Sprague-Dawley rats, a unicortical defect was created in the right tibial metaphysis of each rat and a custom-made titanium implant was placed in the left tibia. Animals were then assigned into two groups (n = 12, each group) and treated daily with either propranolol (5 mg/kg: subcutaneous) or saline, for 2 weeks. Then, after killing, the volume of the cortical defects (mm(3)) and the percentages of newly formed bone in the defects, were assessed with microcomputed tomography; bone-implant contact percentage and peri-implant bone volume/tissue volume were assessed by histomorphometry. Result: Propranolol-treated rats presented smaller cortical defects (1.56 +/- 0.28 mm(3) versus 2.04 +/- 0.29 mm(3), p < 0.001) with more bone volume/tissue volume (60.6 +/- 7.9% versus 41.1 +/- 10.2%, p < 0.001) compared to saline-treated rats. Propranolol also enhanced osseointegration as propranolol-treated rats presented higher bone-implant-contact (65.0 +/- 13.1% versus 42.5 +/- 8.8%, p < 0.001) and peri-implant bone volume/Tissue volume (73.8 +/- 10.1% versus 56.9 +/- 5.7%, p = 0.007) than saline-treated rats. Conclusion: Propranolol enhanced bone healing and implant osseointegration.
引用
收藏
页码:1160 / 1170
页数:11
相关论文
共 84 条
[1]   Antimicrobial surfaces for craniofacial implants: state of the art [J].
Actis, Lisa ;
Gaviria, Laura ;
Guda, Teja ;
Ong, Joo L. .
JOURNAL OF THE KOREAN ASSOCIATION OF ORAL AND MAXILLOFACIAL SURGEONS, 2013, 39 (02) :43-54
[2]   Long-term effects of antihypertensive medications on bone mineral density in men older than 55 years [J].
Agacayak, Kamil Serkan ;
Guven, Sedat ;
Koparal, Mahmut ;
Gunes, Nedim ;
Atalay, Yusuf ;
Atilgan, Serhat .
CLINICAL INTERVENTIONS IN AGING, 2014, 9 :509-513
[3]   Efficacy of a Sclerostin Antibody Compared to a Low Dose of PTH on Metaphyseal Bone Healing [J].
Agholme, Fredrik ;
Macias, Brandon ;
Hamang, Matt ;
Lucchesi, Jonathan ;
Adrian, Mary D. ;
Kuhstoss, Stuart ;
Harvey, Anita ;
Sato, Masahiko ;
Aspenberg, Per .
JOURNAL OF ORTHOPAEDIC RESEARCH, 2014, 32 (03) :471-476
[4]   Effects of alendronate on bone healing after tooth extraction in rats [J].
Aguirre, J. I. ;
Altman, M. K. ;
Vanegas, S. M. ;
Franz, S. E. ;
Bassit, A. C. F. ;
Wronski, T. J. .
ORAL DISEASES, 2010, 16 (07) :674-685
[5]   Systemic administration of omeprazole interferes with bone healing and implant osseointegration: an invivo study on rat tibiae [J].
Al Subaie, Ahmed ;
Emami, Elham ;
Tamimi, Iskandar ;
Laurenti, Marco ;
Eimar, Hazem ;
Abdallah, Mohamed-Nur ;
Tamimi, Faleh .
JOURNAL OF CLINICAL PERIODONTOLOGY, 2016, 43 (02) :193-203
[6]   Anti-VEGFs hinder bone healing and implant osseointegration in rat tibiae [J].
Al Subaie, Ahmed Ebraheem ;
Eimar, Hazem ;
Abdallah, Mohamed-Nur ;
Durand, Robert ;
Feine, Jocelyne ;
Tamimi, Faleh ;
Emami, Elham .
JOURNAL OF CLINICAL PERIODONTOLOGY, 2015, 42 (07) :688-696
[7]   Effects of β-adrenergic agonists on bone-resorting activity in human osteoclast-like cells [J].
Arai, M ;
Nagasawa, T ;
Koshihara, Y ;
Yamamoto, S ;
Togari, A .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2003, 1640 (2-3) :137-142
[8]  
Arcangelo V.P., 2006, Pharmacotherapeutics for advanced practice: a practical approach, V536
[9]   Does Beta-blocker Therapy Improve the Survival of Patients with Metastatic Non-small Cell Lung Cancer? [J].
Aydiner, Adnan ;
Ciftci, Rumeysa ;
Karabulut, Senem ;
Kilic, Leyla .
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2013, 14 (10) :6109-6114
[10]   EVIDENCE OF SEQUENTIAL REMODELING IN RAT TRABECULAR BONE - MORPHOLOGY, DYNAMIC HISTOMORPHOMETRY, AND CHANGES DURING SKELETAL MATURATION [J].
BARON, R ;
TROSS, R ;
VIGNERY, A .
ANATOMICAL RECORD, 1984, 208 (01) :137-145