SPECIFICITY AND SELECTIVITY IMPROVEMENT IN DOPING ANALYSIS USING COMPREHENSIVE TWO-DIMENSIONAL GAS CHROMATOGRAPHY COUPLED WITH TIME-OF-FLIGHT MASS SPECTROMETRY

被引：4

作者：

Barbosa, Samantha S. ^{[1
]}

Leal, Felipe D. ^{[1
]}

Padilha, Monica C. ^{[1
]}

Silva, Raphael S. F. ^{[1
]}

Pereira, Henrique Marcelo G. ^{[1
]}

Aquino Neto, Francisco R. ^{[1
]}

da Silva Junior, Ademrio I. ^{[2
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Quim, BR-21949900 Rio De Janeiro, RJ, Brazil

[2] Inst Fed Educ Ciencia & Tecnol Rio de Janeiro, BR-20270021 Rio De Janeiro, RJ, Brazil

来源：

QUIMICA NOVA | 2012年 / 35卷 / 05期

关键词：

comprehensive two-dimensional gas chromatography; doping analysis; time-of-flight; X GC; ANABOLIC-STEROIDS; SPECIAL EMPHASIS; TETRAHYDROGESTRINONE; IDENTIFICATION; STANOZOLOL; GAMES; OIL;

D O I：

10.1590/S0100-40422012000500022

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry was used for the identification of forty doping agents. The improvement in the specificity was remarkable, allowing the resolution of analytes that could not be done by one-dimensional chromatographic systems. The sensitivity observed for different classes of prohibited substances was clearly below the value required by the World Anti-Doping Agency. In addition time-of-flight mass spectrometry gives full spectrum for all analytes without any interference from the matrix, resulting in selectivity improvements. These results could support the implementation of an exhaustive monitoring approach for hundreds of doping agents in a single injection.

引用

页码：982 / U359

页数：7

共 37 条

[1] Recent developments in comprehensive two-dimensional gas chromatography (GC X GC) I. Introduction and instrumental set-up [J].

Adahchour, M. ;

Beens, J. ;

Vreuls, R. J. J. ;

Brinkman, U. A. Th .

TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2006, 25 (05) :438-454

[2] Recent developments in comprehensive two-dimensional gas chromatography (GC x GC) II. Modulation and detection [J].

Adahchour, M ;

Beens, J ;

Vreuls, RJJ ;

Brinkman, UAT .

TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2006, 25 (06) :540-553

[3]

[Anonymous], 2005, 170252005 ABNT NBR I

[4]

[Anonymous], 2007, RECENT ADV DOPING AN

[5] Chemical characterization of aromatic compounds in extra heavy gas oil by comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry [J].

Avila, Barbara M. F. ;

Pereira, Ricardo ;

Gomes, Alexandre O. ;

Azevedo, Debora A. .

JOURNAL OF CHROMATOGRAPHY A, 2011, 1218 (21) :3208-3216

[6] A half-century of anabolic steroids in sport [J].

Bowers, Larry D. ;

Clark, Richard V. ;

Shackleton, Cedric H. L. .

STEROIDS, 2009, 74 (03) :285-287

[7] Establishing an alternative method for the quantitative analysis of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans by comprehensive two dimensional gas chromatography-time-of-flight mass spectrometry for developing countries [J].

de Vos, Jayne ;

Gorst-Allman, Peter ;

Rohwer, Egmont .

JOURNAL OF CHROMATOGRAPHY A, 2011, 1218 (21) :3282-3290

[8] The detection of doping by means of chromatographic methods [J].

Donike, Manfred .

DRUG TESTING AND ANALYSIS, 2011, 3 (01) :15-17

[9] Analysis of organic compounds of water-in-crude oil emulsions separated by microwave heating using comprehensive two-dimensional gas chromatography and time-of-flight mass spectrometry [J].

Freitas, Lisiane S. ;

Von Muhlen, Carin ;

Bortoluzzi, Janaina H. ;

Zini, Claudia A. ;

Fortuny, Montserrat ;

Dariva, Claudio ;

Coutinho, Raquel C. C. ;

Santos, Alexandre F. ;

Caramao, Elina B. .

JOURNAL OF CHROMATOGRAPHY A, 2009, 1216 (14) :2860-2865

[10] Headspace solid-phase microextraction combined with GC x GC-TOFMS for the analysis of volatile compounds of Coptis species rhizomes [J].

Gao, Xin ;

Yang, Xiuwei ;

Mitrevski, Blagoj S. ;

Marriott, Philip J. .

JOURNAL OF SEPARATION SCIENCE, 2011, 34 (10) :1157-1166

← 1 2 3 4 →