Design, synthesis and biological evaluation of 1,3-diaminopropanes: A new class of polyamine analogs as leishmanicidal agents

被引：7

作者：

Kumar, V

Singh, SK

Sharma, S

Bhaduri, AP

Gupta, S

Zaidi, A

Tiwari, S

Katiyar, JC

机构：

[1] CENT DRUG RES INST,DEPT MED CHEM,LUCKNOW 226001,UTTAR PRADESH,INDIA

[2] CENT DRUG RES INST,DEPT PARASITOL,LUCKNOW 226001,UTTAR PRADESH,INDIA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(97)00087-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Analogs of I,S-diaminopropane as inhibitors for the growth of Leishmania donovani have been synthesized and evaluated,for their antileishmanial activity. Of the many active compounds, 1-(3-N,N-bis methoxycarbonyl guanidino)propyl-4-methylpiperidine piperazine (4e,f) exhibited significant in vivo inhibitory efficacy against L. donovani by oral and intraperitoneal route of administration. (C) 1997 Elsevier Science Ltd.

引用

页码：675 / 680

页数：6

共 8 条

[1]

BACHRACH U, 1981, MED BIOL, V59, P441

[2] SUPPRESSION OF BOTH ANTIMONY-SUSCEPTIBLE AND ANTIMONY-RESISTANT LEISHMANIA-DONOVANI BY A BIS(BENZYL)POLYAMINE ANALOG [J].