GATA transcription factors and cardiac development

被引：204
作者：
Charron, F
Nemer, M
机构：
[1] Inst Rech Clin Montreal, Lab Dev & Differenciat Cardiaq, Montreal, PQ H2W 1R7, Canada
[2] McGill Univ, Dept Med, Div Expt Med, Montreal, PQ, Canada
[3] Univ Montreal, Dept Pharmacol, Montreal, PQ H3C 3J7, Canada
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 1999年 / 10卷 / 01期
基金：
英国医学研究理事会;
关键词：
embryonic development; GATA factors; heart; transcription; ventricular hypertrophy;
D O I：
10.1006/scdb.1998.0281
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Three members of the GATA family of transcription factors, GATA-4, -5, and -6, are expressed in the developing heart. One family member, GATA-5, is restricted to the endocardium while the other two, GATA-4 and -6, are present in the myocardium where they apparently fulfil distinct functions. The mechanisms underlying GATA factor specificity are not fully understood but may involve interaction with other tissue-restricted or ubiquitous co-factors. Thus, combinatorial interaction among GATA factors or between GATA factors and other co-factors may differentially control various stages of cardiogenesis.
引用
收藏
页码：85 / 91
页数：7
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