Nick Your DNA, Mark Your Chromatin

被引:0
作者
Nardozza, Aurelio P. [1 ]
Ladurner, Andreas G. [1 ,2 ,3 ]
机构
[1] Ludwig Maximilians Univ Munchen, Physiol Chem, Biomed Ctr, Grosshaderner St 9, D-82152 Planegg Martinsried, Germany
[2] CIPSM, D-81377 Munich, Germany
[3] Munich Cluster Syst Neurol SyNergy, D-80336 Munich, Germany
基金
英国医学研究理事会;
关键词
PEPTIDES; TARGETS; REVEALS; PARP-1;
D O I
10.1016/j.molcel.2016.09.023
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
DNA damage induces chemical and structural changes in our chromatin-embedded genome. In a recent issue of Nature Communications, Grundy et al. (2016) identify a role for PARP3 in the repair of single-strand breaks and reveal that PARP3 mono-ADP-ribosylates nucleosomal histone H2B.
引用
收藏
页码:7 / 9
页数:3
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