Novel associations for coronary artery disease derived from genome wide association studies are not associated with increased carotid intima-media thickness, suggesting they do not act via early atherosclerosis or vessel remodeling

被引：13

作者：

Conde, Lucia ^{[2
]}

Bevan, Steve ^{[1
]}

Sitzer, Matthias ^{[3
]}

Klopp, Norman ^{[4
]}

Illig, Thomas ^{[4
]}

Thiery, Joachim ^{[5
]}

Seissler, Joachim ^{[6
]}

Baumert, Jens ^{[7
]}

Raitakari, Olli ^{[8
,9
]}

Kahonen, Mika ^{[10
,11
]}

Lyytikainen, Leo-Pekka ^{[10
,12
]}

Laaksonen, Reijo ^{[10
,12
]}

Viikari, Jorma ^{[13
]}

Lehtimaki, Terho ^{[10
,12
]}

Koernig, Wolfgang ^{[14
]}

Halperin, Eran ^{[15
,16
]}

Markus, Hugh S. ^{[1
]}

机构：

[1] St Georges Univ London, Stroke & Dementia Res Ctr, London SW17 ORE, England

[2] Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA

[3] JW Goeth Univ, Dept Neurol, Frankfurt, Germany

[4] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany

[5] Univ Leipzig, Inst Lab Med Clin Chem & Mol Diagnost, Leipzig, Germany

[6] Univ Munich, Dept Internal Med, Inst Diabetol, Munich, Germany

[7] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany

[8] Turku Univ Hosp, Dept Clin Physiol, FIN-20520 Turku, Finland

[9] Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland

[10] Tampere Univ Hosp, Tampere, Finland

[11] Univ Tampere, Dept Clin Physiol, FIN-33101 Tampere, Finland

[12] Univ Tampere, Dept Clin Chem, FIN-33101 Tampere, Finland

[13] Univ Turku, Dept Med, Turku, Finland

[14] Univ Ulm, Dept Internal Med Cardiol 2, Med Ctr, Ulm, Germany

[15] Tel Aviv Univ, Edmond J Safra Bioinformat Program, Tel Aviv, Israel

[16] Int Comp Sci Inst, Berkeley, CA 94704 USA

来源：

ATHEROSCLEROSIS | 2011年 / 219卷 / 02期

基金：

芬兰科学院;

关键词：

Coronary artery disease; Atherosclerosis; Genetics; Myocardial infarction; Intima-media thickness; Genome wide association; RISK-FACTORS; PROGRESSION; VARIANTS; EVENTS; LOCUS; WALL;

D O I：

10.1016/j.atherosclerosis.2011.08.031

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Recent genome-wide association studies (GWAS) have identified associations with myocardial infarction and coronary artery disease (CAD), but the mechanisms underlying these associations remain largely unclear. Carotid intima-media thickness (IMT) is a measure of early arterial remodeling and arteriosclerosis. Therefore, if CAD associated SNPs are also associated with carotid IMT; it suggests that they are acting via the early stages of the atherosclerotic process. Methods: In three large community based independent populations (CAPS, KORA and Young Finns) of European ancestry in which common carotid IMT had been measured (total 4961 individuals), we determined whether SNPs that have been associated with CAD in GWAS studies are also associated with carotid IMT. Associations with plaque were not examined. Results: We identified 11 SNPs and one haplotype previously associated with CAD. None of these were associated with common carotid IMT. Conclusions: We found no evidence that SNPs associated with CAD on GWAS are also associated with carotid IMT. This suggests these genetic associations are not acting via early vessel remodeling or early arteriosclerosis. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：684 / 689

页数：6

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