Update on the cellular and molecular aspects of lupus nephritis

被引:43
作者
Frangou, Eleni [1 ,2 ]
Georgakis, Spyros [3 ,4 ,5 ]
Bertsias, George [3 ,4 ,5 ]
机构
[1] Limassol Gen Hosp, Dept Nephrol, Limassol, Cyprus
[2] Acad Athens, Biomed Res Fdn, Athens, Greece
[3] Univ Crete, Med Sch, Rheumatol Clin Immunol & Allergy, Iraklion 71008, Greece
[4] Fdn Res & Technol Hellas FORTH, Inst Mol Biol & Biotechnol, Iraklion, Greece
[5] Univ Hosp Iraklio, Iraklion, Greece
关键词
Autoantibodies; Cytokines; Macrophages; Podocytes; Renal tubular epithelial cells; RNA sequencing; ANTI-DSDNA ANTIBODIES; PLASMACYTOID DENDRITIC CELLS; GERMINAL CENTER FORMATION; IFN-GAMMA RECEPTOR; T-CELLS; B-CELLS; RENAL MACROPHAGES; ERYTHEMATOSUS; CONTRIBUTES; GLOMERULONEPHRITIS;
D O I
10.1016/j.clim.2020.108445
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Recent progress has highlighted the involvement of a variety of innate and adaptive immune cells in lupus nephritis. These include activated neutrophils producing extracellular chromatin traps that induce type I interferon production and endothelial injury, metabolically-rewired IL-17-producing T-cells causing tissue inflammation, follicular and extra-follicular helper T-cells promoting the maturation of autoantibody-producing B-cells that may also sustain the formation of germinal centers, and alternatively activated monocytes/macrophages participating in tissue repair and remodeling. The role of resident cells such as podocytes and tubular epithelial cells is increasingly recognized in regulating the local immune responses and determining the kidney function and integrity. These findings are corroborated by advanced, high-throughput genomic studies, which have revealed an unprecedented amount of data highlighting the molecular heterogeneity of immune and non-immune cells implicated in lupus kidney disease. Importantly, this research has led to the discovery of putative pathogenic pathways, enabling the rationale design of novel treatments.
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页数:12
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