Compact Intraoperative Imaging Device for Sentinel Lymph Node Mapping

被引：1

作者：

Liu, Yang ^{[1
]}

Bauer, Adam Q. ^{[1
]}

Akers, Walter ^{[1
]}

Sudlow, Gail ^{[1
]}

Liang, Kexian ^{[1
]}

Shen, Duanwen ^{[1
]}

Berezin, Mikhail ^{[1
]}

Culver, Joseph P. ^{[1
]}

Achilefu, Samuel ^{[1
]}

机构：

[1] Washington Univ, Dept Radiol, St Louis, MO 63110 USA

来源：

REPORTERS, MARKERS, DYES, NANOPARTICLES, AND MOLECULAR PROBES FOR BIOMEDICAL APPLICATIONS III | 2011年 / 7910卷

关键词：

Fluorescence Imaging; Intraoperative Imaging; Sentinel Lymph Node; Indocyanine Green; Cancer Staging; BREAST-CANCER; CONTRAST AGENTS; ISOSULFAN BLUE; BIOPSY; DYE;

D O I：

10.1117/12.886226

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We have developed a novel real-time intraoperative fluorescence imaging device that can detect near-infrared (NIR) fluorescence and map sentinel lymph nodes (SLNs). In contrast to conventional imaging systems, this device is compact, portable, and battery-operated. It is also wearable and thus allows hands-free operation of clinicians. The system directly displays the fluorescence in its goggle eyepiece, eliminating the need for a remote monitor. Using this device in murine lymphatic mapping, the SLNs stained with indocyanine green (ICG) can be readily detected. Fluorescence-guided SLN resection under the new device was performed with ease. Ex vivo examination of resected tissues also revealed high fluorescence level in the SLNs. Histology further confirmed the lymphatic nature of the resected SLNs.

引用

页数：7

共 15 条

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