Synthesis of 1,5-benzothiazepine derivatives bearing 2-phenoxy-quinoline moiety via 1,3-diplolar cycloaddition reaction

被引：8
|
作者：
Dong, Zhi-Qiang [1 ]
Liu, Fang-Ming [1 ]
Xu, Feng [2 ]
Yuan, Zai-Liang [1 ]
机构：
[1] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 310036, Zhejiang, Peoples R China
[2] Zhejiang Transfar Co Ltd, Hangzhou 311215, Zhejiang, Peoples R China
来源：
MOLECULAR DIVERSITY | 2011年 / 15卷 / 04期
关键词：
1,5-Benzothiazepine; 2-Phenoxy-quinoline; 1,2,4-Oxadiazole; 1,2,4-Triazole; Crystal structure; BIOLOGICAL EVALUATION; ANTAGONISTS; INHIBITORS; ANALOGS;
D O I：
10.1007/s11030-011-9328-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of 1,5-benzothiazepine derivatives were synthesized by the reaction of 1,5-benzothiazepine containing 2-phenoxy-quinoline with benzohydroximinoyl chlorides and hydrazonoyl chlorides at room temperature. The structures of these novel compounds were confirmed by spectrum, elemental, and X-ray crystallographic analysis.
引用
收藏
页码：963 / 970
页数：8
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