Cancer Immunoinformatics: A Promising Era in the Development of Peptide Vaccines for Human Papillomavirus-induced Cervical Cancer

被引：31

作者：

Kaliamurthi, Satyavani ^{[1
,2
]}

Selvaraj, Gurudeeban ^{[1
,2
]}

Junaid, Muhammad ^{[3
]}

Khan, Abbas ^{[3
]}

Gu, Keren ^{[1
,2
]}

Wei, Dong-Qing ^{[1
,3
]}

机构：

[1] Henan Univ Technol, Coll Food Sci & Engn, Ctr Interdisciplinary Sci Computat Life Sci, 100 Lianhua St, Zhengzhou 450001, Henan, Peoples R China

[2] Henan Univ Technol, Coll Chem Chem Engn & Environm, 100 Lianhua St, Zhengzhou 450001, Henan, Peoples R China

[3] Shanghai Jiao Tong Univ, Coll Life Sci & Biotechnol, State Key Lab Microbial Metab, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

来源：

CURRENT PHARMACEUTICAL DESIGN | 2018年 / 24卷 / 32期

基金：

中国博士后科学基金;

关键词：

Cervical cancer; consensus approach; epitopes; human papillomavirus; major histocompatibility complex; vaccine; B-CELL EPITOPES; MHC CLASS-I; HIGH-RISK HPV; RESEARCH DATABASE ISSUE; SVM BASED METHOD; INTRAEPITHELIAL NEOPLASIA; GENOTYPE DISTRIBUTION; HLA-DR; NEUTRALIZING ANTIBODY; ANTIGEN PRESENTATION;

D O I：

10.2174/1381612824666181106094133

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cancer immunoinformatics have led to new directions towards vaccine design from predicted potential epitope candidates, which are able to stimulate the correct cellular or humoral immune responses. They were employed to accomplish an advanced vaccine design through reverse vaccinology by replacing the whole organisms. In this review, computational tools play an essential role in evaluating multiple proteomes to identify and select the potential targeted epitopes or combinations of distinct epitopes, so that candidates may afford a rationale design competent for obtaining suitable cytotoxic T lymphocytes (CTL) or B cell-mediated immune responses. This review is a complete collection of the most beneficial online and user-friendly immunological tools, servers, and databases for the design and development of the peptide vaccine. The mechanism of major histocompatability (MHC)-restricted peptide presentation and how these tools support the vaccine development are also presented. The human papillomavirus (HPV) is taken as a model microbial strain for peptide vaccine design and its sensitization against HPV-induced cervical cancer is discussed.

引用

页码：3791 / 3817

页数：27

共 274 条

[1]

Ahmed Hussain Gadelkarim, 2017, Asian Pac J Cancer Prev, V18, P1543, DOI 10.22034/APJCP.2017.18.6.1543

[2] DEVELOPMENT OF HIGH POTENCY UNIVERSAL DR-RESTRICTED HELPER EPITOPES BY MODIFICATION OF HIGH-AFFINITY DR-BLOCKING PEPTIDES [J].