Cancer Immunoinformatics: A Promising Era in the Development of Peptide Vaccines for Human Papillomavirus-induced Cervical Cancer

被引:31
作者
Kaliamurthi, Satyavani [1 ,2 ]
Selvaraj, Gurudeeban [1 ,2 ]
Junaid, Muhammad [3 ]
Khan, Abbas [3 ]
Gu, Keren [1 ,2 ]
Wei, Dong-Qing [1 ,3 ]
机构
[1] Henan Univ Technol, Coll Food Sci & Engn, Ctr Interdisciplinary Sci Computat Life Sci, 100 Lianhua St, Zhengzhou 450001, Henan, Peoples R China
[2] Henan Univ Technol, Coll Chem Chem Engn & Environm, 100 Lianhua St, Zhengzhou 450001, Henan, Peoples R China
[3] Shanghai Jiao Tong Univ, Coll Life Sci & Biotechnol, State Key Lab Microbial Metab, 800 Dongchuan Rd, Shanghai 200240, Peoples R China
基金
中国博士后科学基金;
关键词
Cervical cancer; consensus approach; epitopes; human papillomavirus; major histocompatibility complex; vaccine; B-CELL EPITOPES; MHC CLASS-I; HIGH-RISK HPV; RESEARCH DATABASE ISSUE; SVM BASED METHOD; INTRAEPITHELIAL NEOPLASIA; GENOTYPE DISTRIBUTION; HLA-DR; NEUTRALIZING ANTIBODY; ANTIGEN PRESENTATION;
D O I
10.2174/1381612824666181106094133
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Cancer immunoinformatics have led to new directions towards vaccine design from predicted potential epitope candidates, which are able to stimulate the correct cellular or humoral immune responses. They were employed to accomplish an advanced vaccine design through reverse vaccinology by replacing the whole organisms. In this review, computational tools play an essential role in evaluating multiple proteomes to identify and select the potential targeted epitopes or combinations of distinct epitopes, so that candidates may afford a rationale design competent for obtaining suitable cytotoxic T lymphocytes (CTL) or B cell-mediated immune responses. This review is a complete collection of the most beneficial online and user-friendly immunological tools, servers, and databases for the design and development of the peptide vaccine. The mechanism of major histocompatability (MHC)-restricted peptide presentation and how these tools support the vaccine development are also presented. The human papillomavirus (HPV) is taken as a model microbial strain for peptide vaccine design and its sensitization against HPV-induced cervical cancer is discussed.
引用
收藏
页码:3791 / 3817
页数:27
相关论文
共 274 条
[1]  
Ahmed Hussain Gadelkarim, 2017, Asian Pac J Cancer Prev, V18, P1543, DOI 10.22034/APJCP.2017.18.6.1543
[2]   DEVELOPMENT OF HIGH POTENCY UNIVERSAL DR-RESTRICTED HELPER EPITOPES BY MODIFICATION OF HIGH-AFFINITY DR-BLOCKING PEPTIDES [J].
ALEXANDER, J ;
SIDNEY, J ;
SOUTHWOOD, S ;
RUPPERT, J ;
OSEROFF, C ;
MAEWAL, A ;
SNOKE, K ;
SERRA, HM ;
KUBO, RT ;
SETTE, A ;
GREY, HM .
IMMUNITY, 1994, 1 (09) :751-761
[3]   HPV DNA methylation at the early promoter and E1/E2 integrity: A comparison between HPV16, HPV18 and HPV45 in cervical cancer [J].
Amaro-Filho, Sergio Menezes ;
Pereira Chaves, Claudia Bessa ;
Felix, Shayany Pinto ;
Basto, Diogo Lisboa ;
de Almeida, Liz Maria ;
Martins Moreira, Miguel Angelo .
PAPILLOMAVIRUS RESEARCH, 2018, 5 :172-179
[4]   Prediction of residues in discontinuous B-cell epitopes using protein 3D structures [J].
Andersen, Pernille Haste ;
Nielsen, Morten ;
Lund, Ole .
PROTEIN SCIENCE, 2006, 15 (11) :2558-2567
[5]   Impaired expression of perforin and granulysin in CD8+ T cells at the site of infection in human chronic pulmonary tuberculosis [J].
Andersson, Jan ;
Samarina, Arina ;
Fink, Joshua ;
Rahman, Sayma ;
Grundstroem, Susanna .
INFECTION AND IMMUNITY, 2007, 75 (11) :5210-5222
[6]  
Anonymous, 2010, Morbidity and Mortality Weekly Report, V59, P626
[7]  
Ansari Hifzur Rahman, 2010, Immunome Res, V6, P6, DOI 10.1186/1745-7580-6-6
[8]   AntigenDB: an immunoinformatics database of pathogen antigens [J].
Ansari, Hifzur Rahman ;
Flower, Darren R. ;
Raghava, G. P. S. .
NUCLEIC ACIDS RESEARCH, 2010, 38 :D847-D853
[9]   Human papillomavirus infection in females with normal cervical cytology: Genotyping and phylogenetic analysis among women in Punjab, Pakistan [J].
Aziz, Hafsa ;
Iqbal, Huma ;
Mahmood, Humera ;
Fatima, Shazia ;
Faheem, Mohammad ;
Sattar, Areej Abdul ;
Tabassum, Sobia ;
Napper, Sanum ;
Batool, Syeda ;
Rasheed, Nuzhat .
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2018, 66 :83-89
[10]   Elevated HPV16 E1 Expression Is Associated with Cervical Cancer Progression [J].
Baedyananda, Fern ;
Chaiwongkot, Arkom ;
Bhattarakosol, Parvapan .
INTERVIROLOGY, 2017, 60 (05) :171-180