Risk factors for death in 1859 subjects with COVID-19

We studied 1859 subjects with confirmed COVID-19 from seven centers in Wuhan 1651 of whom recovered and 208 died. We interrogated diverse covariates for correlations with risk of death from COVID-19. In multi-variable Cox regression analyses increased hazards of in-hospital death were associated with several admission covariates: (1) older age (HR = 1.04; 95% Confidence Interval [CI], 1.03, 1.06peryear increase;P < 0.001); (2) smoking (HR = 1.84 [1.17, 2.92];P = 0.009); (3) admission temperatureper degrees C increase (HR = 1.32 [1.07, 1.64];P = 0.009); (4) Log(10)neutrophil-to-lymphocyte ratio (NLR; HR = 3.30 [2.10, 5.19];P < 0.001); (5) plateletsper10 E + 9/L decrease (HR = 0.996 [0.994, 0.998];P = 0.001); (6) activated partial thromboplastin (aPTT)persecond increase (HR = 1.04 [1.02, 1.05];P < 0.001); (7) Log(10)D-dimerpermg/l increase (HR = 3.00 [2.17, 4.16];P < 0.001); and (8) Log(10)serum creatinineper mu mol/L increase (HR = 4.55 [2.72, 7.62];P < 0.001). In piecewise linear regression analyses Log(10)NLR the interval from >= 0.4 to <= 1.0 was significantly associated with an increased risk of death. Our data identify covariates associated with risk of in hospital death in persons with COVID-19.