The potential of long noncoding RNA therapies

被引：52

作者：

Mercer, Tim R. ^{[1
]}

Munro, Trent ^{[1
]}

Mattick, John S. ^{[2
,3
]}

机构：

[1] Univ Queensland, Australian Inst Biotechnol & Nanomat, St Lucia, Qld, Australia

[2] Univ New South Wales UNSW, Sch Biotechnol & Biomol Biosci, Sydney, NSW, Australia

[3] Univ New South Wales UNSW, RNA Inst, Sydney, Australia

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2022年 / 43卷 / 04期

关键词：

THERAPEUTICS; IDENTIFICATION; TRANSCRIPTION; EXPRESSION; ENHANCER; MAP;

D O I：

10.1016/j.tips.2022.01.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The human genome expresses vast numbers of long noncoding RNAs (lncRNA) that fulfil diverse roles in gene regulation, cell biology, development, and human disease. These roles are often mediated by sequence motifs and secondary structures bound by proteins and can regulate epigenetic, transcriptional, and translational pathways. These functional domains can be further optimised and engineered into RNA devices that are widely used in synthetic biology. We propose that natural lncRNA structures can be explored and exploited for the rational design and assembly of synthetic RNA therapies. This potential has been enabled by advances in the stability, immunogenicity, manufacture, and delivery of other RNA-based therapies, from which we can anticipate the pharmacological properties of lncRNA therapies that have not yet otherwise entered clinical trials.

引用

页码：269 / 280

页数：12

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