Combined heart-liver transplantation: Indications, outcomes and current experience

被引:39
作者
Beal, Eliza W. [1 ]
Mumtaz, Khalid [2 ]
Hayes, Don, Jr. [3 ,4 ]
Whitson, Bryan A. [1 ,5 ]
Black, Sylvester M. [1 ,6 ]
机构
[1] Ohio State Univ, Wexner Med Ctr, Dept Surg, Columbus, OH 43210 USA
[2] Ohio State Wexner Med Ctr, Div Gastroenterol Hepatol & Nutr, Dept Internal Med, Columbus, OH USA
[3] Ohio State Univ, Coll Med, Dept Pediat, Columbus, OH 43210 USA
[4] Ohio State Univ, Coll Med, Dept Internal Med, Columbus, OH 43210 USA
[5] Ohio State Univ, Wexner Med Ctr, Dept Surg, Div Cardiothorac Surg, Columbus, OH 43210 USA
[6] Ohio State Univ, Wexner Med Ctr, Dept Surg, Div Transplantat Surg, Columbus, OH 43210 USA
关键词
SINGLE-CENTER EXPERIENCE; OF-THE-LITERATURE; HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA; COMBINED ORTHOTOPIC HEART; HETEROZYGOUS HYPERCHOLESTEROLEMIA; PERIOPERATIVE MANAGEMENT; ANESTHETIC MANAGEMENT; CARDIAC GRAFT; UNITED-STATES; PATIENT;
D O I
10.1016/j.trre.2016.07.001
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Combined heart-liver transplantation is a rare, life-saving procedure that treats complex and often fatal diseases including familial amyloidosis polyneuropathy and late stage congenital heart disease status-post previous repair. There were 159 combined heart-liver transplantations performed between January 1,1988 and October 3, 2014 in the United States. A multitude of potential techniques to be used for combined heart and liver transplant including: orthotopic heart transplant (OHT) and orthotopic liver transplant (OLT) on full cardiopulmonary bypass (CPB), OHT with CPB and OLT with venovenous bypass (WB), OHT with CPB and OLT without WB, en bloc technique and sequential transplantation. Outcomes of combined heart-liver transplant have been demonstrated to be comparable to outcomes of isolated heart and isolated liver transplant. The liver graft may provide some tolerance of other allografts (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码:261 / 268
页数:8
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