Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naive/memory Breg ratio during a relapse but not in remission

被引:152
作者
Knippenberg, Stephanie [1 ,2 ,3 ]
Peelen, Evelyn [1 ,2 ,3 ]
Smolders, Joost [1 ,2 ,3 ]
Thewissen, Marielle [2 ]
Menheere, Paul [4 ]
Tervaert, Jan Willem Cohen [1 ,2 ,5 ]
Hupperts, Raymond [1 ,3 ]
Damoiseaux, Jan [5 ]
机构
[1] Maastricht Univ Med Ctr, Sch Mental Hlth & Neurosci, NL-6200 MD Maastricht, Netherlands
[2] Maastricht Univ Med Ctr, Dept Internal Med, Div Clin & Expt Immunol, NL-6200 MD Maastricht, Netherlands
[3] Orbis Med Ctr, Acad MS Ctr Limburg, Sittard, Netherlands
[4] Maastricht Univ Med Ctr, Dept Clin Chem, NL-6200 MD Maastricht, Netherlands
[5] Maastricht Univ Med Ctr, Clin Immunol Lab, NL-6200 MD Maastricht, Netherlands
关键词
Multiple sclerosis; B cell; Regulatory B cell; Vitamin D; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; 1,25-DIHYDROXYVITAMIN D-3; MEMORY; RITUXIMAB; SUBSETS; DIFFERENTIATION; NATALIZUMAB; PROFILES;
D O I
10.1016/j.jneuroim.2011.08.019
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In this study, we assessed B cell subsets, including Bregs, during stable and active disease in relapsing remitting multiple sclerosis (RRMS) patients and related B cell subsets to vitamin D status. We report that RRMS patients have a decreased percentage of both memory B cells and Bregs compared to healthy controls. During a relapse, the reduction in Bregs involved in particular naive Bregs. We found no correlation between vitamin D status and B cell subsets. An effect of vitamin Don Bregs cannot be ruled out, since it might be the function that is interfered with instead of relative numbers. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:80 / 86
页数:7
相关论文
共 34 条
[11]   B cells regulate autoimmunity by provision of IL-10 [J].
Fillatreau, S ;
Sweenie, CH ;
McGeachy, MJ ;
Gray, D ;
Anderton, SM .
NATURE IMMUNOLOGY, 2002, 3 (10) :944-950
[12]   Memory B cells from a subset of treatment-naive relapsing-remitting multiple sclerosis patients elicit CD4+ T-cell proliferation and IFN-γ production in response to myelin basic protein and myelin oligodendrocyte glycoprotein [J].
Harp, Christopher T. ;
Ireland, Sara ;
Davis, Laurie S. ;
Remington, Gina ;
Cassidy, Bonnie ;
Cravens, Petra D. ;
Stuve, Olaf ;
Lovett-Racke, Amy E. ;
Eagar, Todd N. ;
Greenberg, Benjamin M. ;
Racke, Michael K. ;
Cowell, Lindsay G. ;
Karandikar, Nitin J. ;
Frohman, Elliot M. ;
Monson, Nancy L. .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2010, 40 (10) :2942-2956
[13]   B-cell depletion with Rituximab in relapsing-remitting multiple sclerosis [J].
Hauser, Stephen L. ;
Waubant, Emmanuelle ;
Arnold, Douglas L. ;
Vollmer, Timothy ;
Antel, Jack ;
Fox, Robert J. ;
Bar-Or, Amit ;
Panzara, Michael ;
Sarkar, Neena ;
Agarwal, Sunil ;
Langer-Gould, Annette ;
Smith, Craig H. .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (07) :676-688
[14]   1,25-dihydroxYvitamin D3 promotes IL-10 production in human B cells [J].
Heine, Guido ;
Niesner, Uwe ;
Chang, Hyun-Dong ;
Steinmeyer, Andreas ;
Zuegel, Ulrich ;
Zuberbier, Torsten ;
Radbruch, Andreas ;
Worm, Margitta .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (08) :2210-2218
[15]   Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis [J].
Hirotani, Makoto ;
Niino, Masaaki ;
Fukazawa, Toshiyuki ;
Kikuchi, Seiji ;
Yabe, Ichiro ;
Hamada, Shinsuke ;
Tajima, Yasutaka ;
Sasaki, Hidenao .
JOURNAL OF NEUROIMMUNOLOGY, 2010, 221 (1-2) :95-100
[16]  
HOLMOY T, 2011, ACTA NEUROL SCAND, DOI DOI 10.1111/J1600-0404.2011.01577.X
[17]   Effect of vitamin D3 supplementation on peripheral B cell differentiation and isotype switching in patients with multiple sclerosis [J].
Knippenberg, Stephanie ;
Smolders, Joost ;
Thewissen, Marielle ;
Peelen, Evelyn ;
Tervaert, Jan Willem Cohen ;
Hupperts, Raymond ;
Damoiseaux, Jan .
MULTIPLE SCLEROSIS JOURNAL, 2011, 17 (12) :1418-1423
[18]   Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis [J].
Krumbholz, M. ;
Meinl, I. ;
Kuempfel, T. ;
Hohlfeld, R. ;
Meinl, E. .
NEUROLOGY, 2008, 71 (17) :1350-1354
[19]   B-cell subsets up-regulate α4 integrin and accumulate in the cerebrospinal fluid in clinically isolated syndrome suggestive of multiple sclerosis onset [J].
Lee-Chang, Catalina ;
Zephir, Helene ;
Top, Isabelle ;
Dubucquoi, Sylvain ;
Trauet, Jacques ;
Prin, Lionel ;
Vermersch, Patrick .
NEUROSCIENCE LETTERS, 2011, 487 (03) :273-277
[20]   Human T cells induce their own regulation through activation of B cells [J].
Lemoine, Sebastien ;
Morva, Ahsen ;
Youinou, Pierre ;
Jamin, Christophe .
JOURNAL OF AUTOIMMUNITY, 2011, 36 (3-4) :228-238