Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naive/memory Breg ratio during a relapse but not in remission

被引：152

作者：

Knippenberg, Stephanie ^{[1
,2
,3
]}

Peelen, Evelyn ^{[1
,2
,3
]}

Smolders, Joost ^{[1
,2
,3
]}

Thewissen, Marielle ^{[2
]}

Menheere, Paul ^{[4
]}

Tervaert, Jan Willem Cohen ^{[1
,2
,5
]}

Hupperts, Raymond ^{[1
,3
]}

Damoiseaux, Jan ^{[5
]}

机构：

[1] Maastricht Univ Med Ctr, Sch Mental Hlth & Neurosci, NL-6200 MD Maastricht, Netherlands

[2] Maastricht Univ Med Ctr, Dept Internal Med, Div Clin & Expt Immunol, NL-6200 MD Maastricht, Netherlands

[3] Orbis Med Ctr, Acad MS Ctr Limburg, Sittard, Netherlands

[4] Maastricht Univ Med Ctr, Dept Clin Chem, NL-6200 MD Maastricht, Netherlands

[5] Maastricht Univ Med Ctr, Clin Immunol Lab, NL-6200 MD Maastricht, Netherlands

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2011年 / 239卷 / 1-2期

关键词：

Multiple sclerosis; B cell; Regulatory B cell; Vitamin D; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; 1,25-DIHYDROXYVITAMIN D-3; MEMORY; RITUXIMAB; SUBSETS; DIFFERENTIATION; NATALIZUMAB; PROFILES;

D O I：

10.1016/j.jneuroim.2011.08.019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, we assessed B cell subsets, including Bregs, during stable and active disease in relapsing remitting multiple sclerosis (RRMS) patients and related B cell subsets to vitamin D status. We report that RRMS patients have a decreased percentage of both memory B cells and Bregs compared to healthy controls. During a relapse, the reduction in Bregs involved in particular naive Bregs. We found no correlation between vitamin D status and B cell subsets. An effect of vitamin Don Bregs cannot be ruled out, since it might be the function that is interfered with instead of relative numbers. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.

引用

页码：80 / 86

页数：7

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