Nobiletin in Cancer Therapy: How This Plant Derived-Natural Compound Targets Various Oncogene and Onco-Suppressor Pathways

被引：71

作者：

Ashrafizadeh, Milad ^{[1
]}

Zarrabi, Ali ^{[2
]}

Saberifar, Sedigheh ^{[3
]}

Hashemi, Farid ^{[4
]}

Hushmandi, Kiavash ^{[5
]}

Hashemi, Fardin ^{[6
]}

Moghadam, Ebrahim Rahmani ^{[7
]}

Mohammadinejad, Reza ^{[8
]}

Najafi, Masoud ^{[9
]}

Garg, Manoj ^{[10
]}

机构：

[1] Univ Tabriz, Fac Vet Med, Dept Basic Sci, Tabriz 5166616471, Iran

[2] Sabanci Univ, Nanotechnol Res & Applicat Ctr SUNUM, TR-34956 Istanbul, Turkey

[3] Shahid Chamran Univ Ahvaz, Fac Vet Med, Dept Basic Sci, Ahvaz 6135783151, Iran

[4] Islamic Azad Univ, Kazerun Branch, Young Researcher & Elite Club, Kazeroon 7319846451, Iran

[5] Univ Tehran, Fac Vet Med, Div Epidemiol, Dept Food Hyg & Qual Control, Tehran 1417414418, Iran

[6] Ahvaz Jundishapur Univ Med Sci, Fac Rehabil, Dept Physiotherapy, Student Res Comm, Ahvaz 6135715749, Iran

[7] Shiraz Univ Med Sci, Sch Med, Dept Anat Sci, Student Res Comm, Shiraz 7134814336, Iran

[8] Kerman Univ Med Sci, Inst Neuropharmacol, Neurosci Res Ctr, Kerman 7619813159, Iran

[9] Kermanshah Univ Med Sci, Sch Paramed Sci, Radiol & Nucl Med Dept, Kermanshah 6715847141, Iran

[10] Amity Univ Uttar Pradesh, Amity Inst Mol Med & Stem Cell Res AIMMSCR, Sect 125, Noida 201313, India

来源：

BIOMEDICINES | 2020年 / 8卷 / 05期

关键词：

nobiletin; flavonoid; citrus; cancer therapy; signaling pathway; herbal compound; EPITHELIAL-MESENCHYMAL TRANSITION; CELL-CYCLE ARREST; INHIBITS TUMOR-GROWTH; CARCINOMA IN-VITRO; LUNG-CANCER; SIGNALING PATHWAY; OXIDATIVE STRESS; HUMAN BREAST; CITRUS NOBILETIN; GENE-EXPRESSION;

D O I：

10.3390/biomedicines8050110

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer therapy is a growing field, and annually, a high number of research is performed to develop novel antitumor drugs. Attempts to find new antitumor drugs continue, since cancer cells are able to acquire resistance to conventional drugs. Natural chemicals can be considered as promising candidates in the field of cancer therapy due to their multiple-targeting capability. The nobiletin (NOB) is a ubiquitous flavone isolated from Citrus fruits. The NOB has a variety of pharmacological activities, such as antidiabetes, antioxidant, anti-inflammatory, hepatoprotective, and neuroprotective. Among them, the antitumor activity of NOB has been under attention over recent years. In this review, we comprehensively describe the efficacy of NOB in cancer therapy. NOB induces apoptosis and cell cycle arrest in cancer cells. It can suppress migration and invasion of cancer cells via the inhibition of epithelial-to-mesenchymal transition (EMT) and EMT-related factors such as TGF-beta, ZEB, Slug, and Snail. Besides, NOB inhibits oncogene factors such as STAT3, NF-kappa B, Akt, PI3K, Wnt, and so on. Noteworthy, onco-suppressor factors such as microRNA-7 and -200b undergo upregulation by NOB in cancer therapy. These onco-suppressor and oncogene pathways and mechanisms are discussed in this review.

引用

页数：31

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