Three-dimensional coordination polymers based on trimethyltin cation with nicotinic and isonicotinic acids as anticancer agents

Two new coordination polymers, namely [Me3Sn(INA)] (CP1) and [Me3Sn(NA)] (CP2), where INA=isonicotinic acid and NA=nicotinic acid, were characterized using infrared, UV-visible and NMR spectroscopies, thermogravimetric analysis and single-crystal X-ray analyses. The structure of CP1 consists of a one-dimensional coordinated chain which is further extended creating a two-dimensional layer via hydrogen bonds. The two-dimensional layers propagate along the corresponding planes creating a three-dimensional framework by hydrogen bonding and edge-to-face - stacking. The asymmetric unit of CP2 contains one tin atom and one NA ligand exhibiting 1:1 stoichiometry. The structure of CP2 extends through coordination bonds to form a one-dimensional zigzag chain which further extends to create a three-dimensional network via crossing chains and hydrogen bonds. The tin atoms acquire distorted trigonal bipyramid (TBPY-5) geometry. CP1 and CP2 were designed to investigate their cytotoxic properties against various human cancer cell lines: hepatocellular carcinoma, mammary gland breast cancer, human prostate cancer and colorectal carcinoma. The compounds are good anticancer agents against the tested cell lines. Also they were screened for their antioxidant, anti-haemolytic, antibacterial and antifungal activities.