Metabolic engineering in methanotrophic bacteria

被引：231

作者：

Kalyuzhnaya, Marina G. ^{[1
,3
]}

Puri, Aaron W. ^{[2
]}

Lidstrom, Mary E. ^{[2
,3
]}

机构：

[1] San Diego State Univ, Dept Biol, San Diego, CA 92182 USA

[2] Univ Washington, Dept Chem Engn, Seattle, WA 98195 USA

[3] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA

来源：

METABOLIC ENGINEERING | 2015年 / 29卷

关键词：

Natural gas; Methanotroph; Metabolic engineering; SOLUBLE METHANE MONOOXYGENASE; METHYLOSINUS-TRICHOSPORIUM OB3B; METHYLOCOCCUS-CAPSULATUS BATH; GENOME-SCALE RECONSTRUCTION; PROMOTER-PROBE VECTORS; SINGLE-CELL PROTEIN; ESCHERICHIA-COLI; AMMONIA MONOOXYGENASE; GENE-EXPRESSION; ACID PRODUCTION;

D O I：

10.1016/j.ymben.2015.03.010

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Methane, as natural gas or biogas, is the least expensive source of carbon for (bio)chemical synthesis. Scalable biological upgrading of this simple alkane to chemicals and fuels can bring new sustainable solutions to a number of industries with large environmental footprints, such as natural gas/petroleum production, landfills, wastewater treatment, and livestock. Microbial biocatalysis with methane as a feedstock has been pursued off and on for almost a half century, with little enduring success. Today, biological engineering and systems biology provide new opportunities for metabolic system modulation and give new optimism to the concept of a methane-based bio-industry. Here we present an overview of the most recent advances pertaining to metabolic engineering of microbial methane utilization. Some ideas concerning metabolic improvements for production of acetyl-CoA and pyruvate, two main precursors for bioconversion, are presented. We also discuss main gaps in the current knowledge of aerobic methane utilization, which must be solved in order to release the full potential of methane-based biosystems. (C) 2015 International Metabolic Engineering Society. Published by Elsevier Inc. All rights reserved.

引用

页码：142 / 152

页数：11

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