Delayed respiratory syncytial virus outbreak in 2020 in Taiwan was correlated with two novel RSV-A genotype ON1 variants

被引:24
作者
Lee, Chun Yi [1 ,2 ]
Wu, Tsung Hua [3 ]
Fang, Yu Ping [1 ]
Chang, Jih Chin [1 ]
Wang, Hung Chun [1 ]
Lin, Shou Ju [1 ]
Mai, Chen Hao [1 ]
Chang, Yu Chuan [1 ]
Chou, Teh Ying [2 ,4 ]
机构
[1] Chang Bing Show Chwan Mem Hosp, Dept Pediat, Changhua, Taiwan
[2] Natl Yang Ming Chiao Tung Univ, Inst Clin Med, Taipei, Taiwan
[3] Show Chwan Mem Hosp, Dept Pediat, Changhua, Taiwan
[4] Taipei Vet Gen Hosp, Dept Pathol & Lab Med, Taipei, Taiwan
关键词
epidemiology; genotype; respiratory syncytial virus; Taiwan; CHILDREN; INFECTION; HOSPITALIZATION; PROTEIN; BURDEN; ADULTS;
D O I
10.1111/irv.12951
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background Human respiratory syncytial virus (RSV) is a leading pathogen of acute respiratory tract disease among infants and young children. Compared with previous seasons, RSV outbreaks in Taiwan during the 2020-2021 season were delayed because of COVID-19 mitigation measures. We conducted this study to determine the association of viral factors with clinical characteristics of preschool children with RSV infection. Methods We performed a molecular epidemiology analysis of RSV among inpatient preschool children in Taiwan. In 80 nasopharyngeal samples positive for RSV, we sequenced and analyzed viral genotypes according to patient data. Patients' clinical data were obtained from medical files, and their clinical profiles were compared with those of RSV cases recorded during the 2014-2017 seasons. Results Phylogenetic analysis revealed that among the RSV-positive samples, all RSV strains identified during the 2020-2021 season belonged to the ON1 genotype. Most of the Taiwan ON1 strains were categorized into two well-supported clusters with distinct G protein amino acid substitution patterns that had never been demonstrated previously. Furthermore, the proportion of cases among children aged >24 months increased (P < 0.001). Compared with patients infected during the 2014-2017 seasons, patients infected during the 2020-2021 season were hospitalized for shorter days from hospital admission to dereference (P = 0.004) and had a greater need for oxygen supplements (P = 0.021) and systemic steroid therapy (P = 0.026). Conclusion The delayed 2020-2021 RSV outbreak in Taiwan was caused by two novel RSV ON1.1 variants. How the change in RSV epidemiology affects future RSV outbreaks warrants exploration.
引用
收藏
页码:511 / 520
页数:10
相关论文
共 30 条
  • [1] Delayed Seasonal RSV Surge Observed During the COVID-19 Pandemic
    Agha, Rabia
    Avner, Jeffrey R.
    [J]. PEDIATRICS, 2021, 148 (03)
  • [2] RSV Strains and Disease Severity
    Anderson, Larry J.
    Peret, Teresa C.
    Piedra, Pedro A.
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2019, 219 (04) : 514 - 516
  • [3] A prospective surveillance study on the kinetics of the humoral immune response to the respiratory syncytial virus fusion protein in adults in Houston, Texas
    Blunck, Brittani N.
    Aideyan, Letisha
    Ye, Xunyan
    Avadhanula, Vasanthi
    Ferlic-Stark, Laura
    Zechiedrich, Lynn
    Gilbert, Brian E.
    Piedra, Pedro A.
    [J]. VACCINE, 2021, 39 (08) : 1248 - 1256
  • [4] Natural reinfection with respiratory syncytial virus does not boost virus-specific T-cell immunity
    Bont, L
    Versteegh, J
    Swelsen, WTN
    Heijnen, CJ
    Kavelaars, A
    Brus, F
    Draaisma, JMT
    Pekelharing-Berghuis, M
    Van Diemen-Steenvoorde, RAAM
    Kimpen, JLL
    [J]. PEDIATRIC RESEARCH, 2002, 52 (03) : 363 - 367
  • [5] Characteristics of the delayed respiratory syncytial virus epidemic, 2020/2021, Rhone Loire, France
    Casalegno, Jean-Sebastien
    Ploin, Dominique
    Cantais, Aymeric
    Masson, Elsa
    Bard, Emilie
    Valette, Martine
    Fanget, Remi
    Targe, Sandrine Couray
    Myar-Dury, Anne-Florence
    Doret-Dion, Muriel
    Massoud, Mona
    Queromes, Gregory
    Vanhems, Philippe
    Claris, Olivier
    Butin, Marine
    Pillet, Sylvie
    Ader, Florence
    Bin, Sylvie
    Gaymard, Alexandre
    Lina, Bruno
    Morfin, Florence
    Javouhey, Etienne
    Gillet, Yves
    [J]. EUROSURVEILLANCE, 2021, 26 (29)
  • [6] Persistence and continuous evolution of the human respiratory syncytial virus in northern Taiwan for two decades
    Chi, Hsin
    Hsiao, Kuang-Liang
    Weng, Li-Chuan
    Liu, Chang-Pan
    Liu, Hsin-Fu
    [J]. SCIENTIFIC REPORTS, 2019, 9 (1)
  • [7] Epidemiological Study of Hospitalization Associated With Respiratory Syncytial Virus Infection in Taiwanese Children Between 2004 and 2007
    Chi, Hsin
    Chang, I-Shou
    Sai, Fang-Yu
    Huang, Li-Min
    Shao, Pei-Lan
    Chiu, Nan-Chang
    Chang, Luan-Yin
    Huang, Fu-Yuan
    [J]. JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 2011, 110 (06) : 388 - 396
  • [8] Genetic diversity and evolutionary insights of respiratory syncytial virus A ON1 genotype: global and local transmission dynamics
    Duvvuri, Venkata R.
    Granados, Andrea
    Rosenfeld, Paul
    Bahl, Justin
    Eshaghi, Alireza
    Gubbay, Jonathan B.
    [J]. SCIENTIFIC REPORTS, 2015, 5
  • [9] Characteristics and Their Clinical Relevance of Respiratory Syncytial Virus Types and Genotypes Circulating in Northern Italy in Five Consecutive Winter Seasons
    Esposito, Susanna
    Piralla, Antonio
    Zampiero, Alberto
    Bianchini, Sonia
    Di Pietro, Giada
    Scala, Alessia
    Pinzani, Raffaella
    Fossali, Emilio
    Baldanti, Fausto
    Principi, Nicola
    [J]. PLOS ONE, 2015, 10 (06):
  • [10] Antigenic Fingerprinting following Primary RSV Infection in Young Children Identifies Novel Antigenic Sites and Reveals Unlinked Evolution of Human Antibody Repertoires to Fusion and Attachment Glycoproteins
    Fuentes, Sandra
    Coyle, Elizabeth M.
    Beeler, Judy
    Golding, Hana
    Khurana, Surender
    [J]. PLOS PATHOGENS, 2016, 12 (04)