Advanced smart-photosensitizers for more effective cancer treatment

被引：92

作者：

Park, Wooram ^{[1
]}

Cho, Soojeong ^{[1
]}

Han, Jieun ^{[2
]}

Shin, Heejun ^{[2
]}

Na, Kun ^{[2
]}

Lee, Byeongdu ^{[3
]}

Kim, Dong-Hyun ^{[1
,4
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Radiol, Chicago, IL 60611 USA

[2] Catholic Univ Korea, Dept Biotechnol, Ctr Photomed, Bucheon Si 14662, Gyeonggi Do, South Korea

[3] Argonne Natl Lab, Xray Sci Div, 9700 S Cass Ave, Argonne, IL 60439 USA

[4] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

来源：

BIOMATERIALS SCIENCE | 2017年 / 6卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

UP-CONVERSION NANOPARTICLES; PHOTODYNAMIC THERAPY; CHECKPOINT BLOCKADE; POLYMERIC PHOTOSENSITIZER; DRUG-DELIVERY; MAGNETIC MICROSPHERES; ANTITUMOR IMMUNITY; ACTINIC KERATOSIS; IN-VITRO; PHASE-I;

D O I：

10.1039/c7bm00872d

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Photodynamic therapy (PDT) based upon the use of light and photosensitizers (PSs) has been used as a novel treatment approach for a variety of tumors. It, however, has several major limitations in the clinic: poor water solubility, long-term phototoxicity, low tumor targeting efficacy, and limited light penetration. With advances in nanotechnology, materials science, and clinical interventional imaging procedures, various smart-PSs have been developed for improving their cancer-therapeutic efficacy while reducing the adverse effects. Here, we briefly review state-of-the-art smart-PSs and discuss the future directions of PDT technology.

引用

页码：79 / 90

页数：12

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