Advanced smart-photosensitizers for more effective cancer treatment

被引：92

作者：

Park, Wooram ^{[1
]}

Cho, Soojeong ^{[1
]}

Han, Jieun ^{[2
]}

Shin, Heejun ^{[2
]}

Na, Kun ^{[2
]}

Lee, Byeongdu ^{[3
]}

Kim, Dong-Hyun ^{[1
,4
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Radiol, Chicago, IL 60611 USA

[2] Catholic Univ Korea, Dept Biotechnol, Ctr Photomed, Bucheon Si 14662, Gyeonggi Do, South Korea

[3] Argonne Natl Lab, Xray Sci Div, 9700 S Cass Ave, Argonne, IL 60439 USA

[4] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

来源：

BIOMATERIALS SCIENCE | 2017年 / 6卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

UP-CONVERSION NANOPARTICLES; PHOTODYNAMIC THERAPY; CHECKPOINT BLOCKADE; POLYMERIC PHOTOSENSITIZER; DRUG-DELIVERY; MAGNETIC MICROSPHERES; ANTITUMOR IMMUNITY; ACTINIC KERATOSIS; IN-VITRO; PHASE-I;

D O I：

10.1039/c7bm00872d

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Photodynamic therapy (PDT) based upon the use of light and photosensitizers (PSs) has been used as a novel treatment approach for a variety of tumors. It, however, has several major limitations in the clinic: poor water solubility, long-term phototoxicity, low tumor targeting efficacy, and limited light penetration. With advances in nanotechnology, materials science, and clinical interventional imaging procedures, various smart-PSs have been developed for improving their cancer-therapeutic efficacy while reducing the adverse effects. Here, we briefly review state-of-the-art smart-PSs and discuss the future directions of PDT technology.

引用

页码：79 / 90

页数：12

共 126 条

[1]

Ackroyd R, 2001, PHOTOCHEM PHOTOBIOL, V74, P656, DOI 10.1562/0031-8655(2001)074<0656:THOPAP>2.0.CO

[2]

[3] Oncologic photodynamic therapy photosensitizers: A clinical review [J].

Allison, Ron R. ;

Sibata, Claudio H. .

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2010, 7 (02) :61-75

[4] Photodynamic therapy for the treatment of nonmelanomatous cutaneous malignancies [J].

Allison, RR ;

Mang, TS ;

Wilson, BD .

SEMINARS IN CUTANEOUS MEDICINE AND SURGERY, 1998, 17 (02) :153-163

[5] Development of Polymeric Cargo for Delivery of Photosensitizer in Photodynamic Therapy [J].

Bae, Byoung-chan ;

Na, Kun .

INTERNATIONAL JOURNAL OF PHOTOENERGY, 2012, 2012

[6] Self-quenching polysaccharide-based nanogels of pullulan/folate-photosensitizer conjugates for photodynamic therapy [J].

Bae, Byoung-chan ;

Na, Kun .

BIOMATERIALS, 2010, 31 (24) :6325-6335

[7] PHOTODYNAMIC THERAPY FOR COLORECTAL-CANCER - A QUANTITATIVE PILOT-STUDY [J].

BARR, H ;

KRASNER, N ;

BOULOS, PB ;

CHATLANI, P ;

BOWN, SG .

BRITISH JOURNAL OF SURGERY, 1990, 77 (01) :93-96

[8] Nanoparticles as vehicles for delivery of photodynamic therapy agents [J].

Bechet, Denise ;

Couleaud, Pierre ;

Frochot, Celine ;

Viriot, Marie-Laure ;

Guillemin, Francois ;

Barberi-Heyob, Muriel .

TRENDS IN BIOTECHNOLOGY, 2008, 26 (11) :612-621

[9] Principles of nanoparticle design for overcoming biological barriers to drug delivery [J].

Blanco, Elvin ;

Shen, Haifa ;

Ferrari, Mauro .

NATURE BIOTECHNOLOGY, 2015, 33 (09) :941-951

[10] Photodynamic therapy for cancer of the pancreas [J].

Bown, SG ;

Rogowska, AZ ;

Whitelaw, DE ;

Lees, WR ;

Lovat, LB ;

Ripley, P ;

Jones, L ;

Wyld, P ;

Gillams, A ;

Hatfield, AWR .

GUT, 2002, 50 (04) :549-557

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