META-ANALYSIS OF SECOND CANCER RISK AFTER RADIOTHERAPY AMONG CHILDHOOD CANCER SURVIVORS

被引:14
作者
Doi, Kazutaka [1 ]
Mieno, Makiko N. [2 ]
Shimada, Yoshiya [1 ]
Yonehara, Hidenori [1 ]
Yoshinaga, Shinji [1 ]
机构
[1] Natl Inst Radiol Sci, Res Ctr Radiat Protect, Inage Ku, Chiba 2638555, Japan
[2] Jichi Med Univ, Ctr Informat, Shimonotsuke, Tochigi 3290498, Japan
关键词
SKIN HEMANGIOMA; MALIGNANT NEOPLASMS; THYROID-CANCER; BREAST-CANCER; SOLID TUMORS; SECONDARY LEUKEMIA; ALKYLATING-AGENTS; 1ST CANCER; RADIATION; CHEMOTHERAPY;
D O I
10.1093/rpd/ncr166
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Cancer risks among childhood cancer survivors following radiotherapy have not yet been well characterised in terms of radiation dose. A meta-analysis of studies on the excess relative risk per gray (ERR) of second cancer was conducted previously; unfortunately, the small number of eligible studies restricted quantitative evaluations. To solve this problem, a statistical method to calculate ERR estimates from other estimates was developed, and a meta-analysis was conducted again. The PubMed database was searched and 26 relevant studies were identified. ERR estimates were available in 15 studies, and for the other 11 studies, the regression-based model was used to calculate ERR estimates from other estimates. The overall ERR estimate was 0.40, which was much lower than that of atomic bomb survivors exposed as young children. Heterogeneity of the risk among studies was suggested, and a further study is needed to explore the heterogeneity among studies.
引用
收藏
页码:263 / 267
页数:5
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