Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective

被引：20
作者：
Miao, Li-na [1 ,2 ]
Pan, Deng [1 ,2 ]
Shi, Junhe [1 ]
Du, Jian-peng [1 ,3 ]
Chen, Peng-fei [1 ]
Gao, Jie [1 ,3 ]
Yu, Yanqiao [1 ,2 ]
Shi, Da-Zhuo [1 ,3 ]
Guo, Ming [1 ,3 ]
机构：
[1] China Acad Chinese Med Sci, Xiyuan Hosp, Beijing, Peoples R China
[2] Beijing Univ Chinese Med, Dept Grad Sch, Beijing, Peoples R China
[3] China Acad Chinese Med Sci, China Heart Inst Chinese Med, Beijing, Peoples R China
来源：
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2022年 / 9卷
基金：
中国国家自然科学基金;
关键词：
cardiovascular disease; PKC-delta; kinase; mechanism; PKC; PROTEIN-KINASE-C; VASCULAR SMOOTH-MUSCLE; TISSUE GROWTH-FACTOR; PERCUTANEOUS CORONARY INTERVENTION; CA2+-ACTIVATED K+ CHANNELS; FOCAL ADHESION KINASE; ANGIOTENSIN-II; TYROSINE PHOSPHORYLATION; MYOCARDIAL-INFARCTION; ACTIVATION MECHANISMS;
D O I：
10.3389/fcvm.2022.816369
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Protein kinase C (PKC) is a protein kinase with important cellular functions. PKC-delta, a member of the novel PKC subfamily, has been well-documented over the years. Activation of PKC-delta plays an important regulatory role in myocardial ischemia/reperfusion (IRI) injury and myocardial fibrosis, and its activity and expression levels can regulate pathological cardiovascular diseases such as atherosclerosis, hypertension, cardiac hypertrophy, and heart failure. This article aims to review the structure and function of PKC-delta, summarize the current research regarding its activation mechanism and its role in cardiovascular disease, and provide novel insight into further research on the role of PKC-delta in cardiovascular diseases.
引用
收藏
页数：16
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