Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective

被引：20

作者：

Miao, Li-na ^{[1
,2
]}

Pan, Deng ^{[1
,2
]}

Shi, Junhe ^{[1
]}

Du, Jian-peng ^{[1
,3
]}

Chen, Peng-fei ^{[1
]}

Gao, Jie ^{[1
,3
]}

Yu, Yanqiao ^{[1
,2
]}

Shi, Da-Zhuo ^{[1
,3
]}

Guo, Ming ^{[1
,3
]}

机构：

[1] China Acad Chinese Med Sci, Xiyuan Hosp, Beijing, Peoples R China

[2] Beijing Univ Chinese Med, Dept Grad Sch, Beijing, Peoples R China

[3] China Acad Chinese Med Sci, China Heart Inst Chinese Med, Beijing, Peoples R China

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2022年 / 9卷

基金：

中国国家自然科学基金;

关键词：

cardiovascular disease; PKC-delta; kinase; mechanism; PKC; PROTEIN-KINASE-C; VASCULAR SMOOTH-MUSCLE; TISSUE GROWTH-FACTOR; PERCUTANEOUS CORONARY INTERVENTION; CA2+-ACTIVATED K+ CHANNELS; FOCAL ADHESION KINASE; ANGIOTENSIN-II; TYROSINE PHOSPHORYLATION; MYOCARDIAL-INFARCTION; ACTIVATION MECHANISMS;

D O I：

10.3389/fcvm.2022.816369

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Protein kinase C (PKC) is a protein kinase with important cellular functions. PKC-delta, a member of the novel PKC subfamily, has been well-documented over the years. Activation of PKC-delta plays an important regulatory role in myocardial ischemia/reperfusion (IRI) injury and myocardial fibrosis, and its activity and expression levels can regulate pathological cardiovascular diseases such as atherosclerosis, hypertension, cardiac hypertrophy, and heart failure. This article aims to review the structure and function of PKC-delta, summarize the current research regarding its activation mechanism and its role in cardiovascular disease, and provide novel insight into further research on the role of PKC-delta in cardiovascular diseases.

引用

页数：16

共 50 条

[31] Current Status of Cardiovascular Medicine in Israel
Kornowski, Ran
Orvin, Katia
CIRCULATION, 2020, 142 (01) : 17 - 19
[32] Update on the Role of Colchicine in Cardiovascular Disease
Darcy Banco
Mohammad Mustehsan
Binita Shah
Current Cardiology Reports, 2024, 26 : 191 - 198
[33] Role of Circular RNAs in Cardiovascular Disease
Kishore, Raj
Garikipati, Venkata N. S.
Gonzalez, Carolina
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2020, 76 (02) : 128 - 137
[34] Role of PKC-δ during hypoxia in heart-derived H9c2 cells
Kim, MJ
Moon, CH
Kim, MH
Lee, SH
Baik, EJ
Jung, YS
JAPANESE JOURNAL OF PHYSIOLOGY, 2004, 54 (04) : 405 - 414
[35] Role of Lipoprotein(a) Reduction in Cardiovascular Disease
Schuth, Uma
Gill, Kieran
Telyuk, Pyotr
Bawamia, Bilal-Reshad
Austin, David
Zaman, Azfar
JOURNAL OF CLINICAL MEDICINE, 2024, 13 (21)
[36] Update on the Role of Colchicine in Cardiovascular Disease
Banco, Darcy
Mustehsan, Mohammad
Shah, Binita
CURRENT CARDIOLOGY REPORTS, 2024, 26 (04) : 191 - 198
[37] The Emerging Role of the Gut Microbiome in Cardiovascular Disease: Current Knowledge and Perspectives
Papadopoulos, Panagiotis D.
Tsigalou, Christina
Valsamaki, Pipitsa N.
Konstantinidis, Theocharis G.
Voidarou, Chrysoula
Bezirtzoglou, Eugenia
BIOMEDICINES, 2022, 10 (05)
[38] The emerging role of microRNAs in cardiovascular disease
Maegdefessel, L.
JOURNAL OF INTERNAL MEDICINE, 2014, 276 (06) : 633 - 644
[39] COVID-19 and Cardiovascular Disease: a Global Perspective
Pina, Alessandra
Castelletti, Silvia
CURRENT CARDIOLOGY REPORTS, 2021, 23 (10)
[40] Work stress and cardiovascular disease: a life course perspective
Li, Jian
Loerbroks, Adrian
Bosma, Hans
Angerer, Peter
JOURNAL OF OCCUPATIONAL HEALTH, 2016, 58 (02) : 216 - 219

← 1 2 3 4 5 →