Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis

被引：90

作者：

Shelton, DL ^{[1
]}

Zeller, J ^{[1
]}

Ho, WH ^{[1
]}

Pons, J ^{[1
]}

Rosenthal, A ^{[1
]}

机构：

[1] Rinat Neurosci Corp, Palo Alto, CA 94304 USA

来源：

PAIN | 2005年 / 116卷 / 1-2期

关键词：

nerve growth factor; arthritis; hyperalgesia; cachexia;

D O I：

10.1016/j.pain.2005.03.039

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Pain and cachexia are two of the most debilitating aspects of rheumatoid arthritis. Despite that, the mechanisms by which they are mediated are not well understood. We provide evidence that nerve growth factor (NGF), a secreted regulatory protein that controls neuronal survival during development, is a key mediator of pain and weight loss in auto-immune arthritis. Function blocking antibodies to NGF completely reverse established pain in rats with fully developed arthritis despite continuing joint destruction and inflammation. Likewise, these antibodies reverse weight loss while not having any effect on levels of the pro-cachectic agent tumor necrosis factor (TNF). Taken together, these findings argue that pathological joint pain and joint destruction are mechanistically independent processes and that NGF regulates an alternative cachexia pathway that is independent or downstream of TNF. (C) 2005 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

引用

页码：8 / 16

页数：9

共 59 条

[1]

ABBADIE C, 1994, J NEUROSCI, V14, P5865

[2] THE SYNOVIUM OF TRANSGENIC ARTHRITIC MICE EXPRESSING HUMAN TUMOR-NECROSIS-FACTOR CONTAINS A HIGH-LEVEL OF NERVE GROWTH-FACTOR [J].