The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity

被引：140

作者：

Bain, Calum C. ^{[1
]}

MacDonald, Andrew S. ^{[2
]}

机构：

[1] Univ Edinburgh, Queens Med Res Inst, Ctr Inflammat Res, Edinburgh EH16 4TJ, Midlothian, Scotland

[2] Univ Manchester, Lydia Becker Inst Immunol & Inflammat, Manchester M13 9NT, Lancs, England

来源：

MUCOSAL IMMUNOLOGY | 2022年 / 15卷 / 02期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

TISSUE-RESIDENT MACROPHAGES; PULMONARY ALVEOLAR PROTEINOSIS; COLONY-STIMULATING FACTOR; CD11B(+) DENDRITIC CELLS; SCAVENGER RECEPTOR MARCO; CYTOKINE GM-CSF; FETAL MONOCYTES; INTERSTITIAL MACROPHAGES; CAVITY MACROPHAGES; CELLULAR-RESPONSE;

D O I：

10.1038/s41385-021-00480-w

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The last decade has been somewhat of a renaissance period for the field of macrophage biology. This renewed interest, combined with the advent of new technologies and development of novel model systems to assess different facets of macrophage biology, has led to major advances in our understanding of the diverse roles macrophages play in health, inflammation, infection and repair, and the dominance of tissue environments in influencing all of these areas. Here, we discuss recent developments in our understanding of lung macrophage heterogeneity, ontogeny, metabolism and function in the context of health and disease, and highlight core conceptual advances and key unanswered questions that we believe should be focus of work in the coming years.

引用

页码：223 / 234

页数：12

共 183 条

[81] IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1 [J].

Jenkins, Stephen J. ;

Ruckerl, Dominik ;

Thomas, Graham D. ;

Hewitson, James P. ;

Duncan, Sheelagh ;

Brombacher, Frank ;

Maizels, Rick M. ;

Hume, David A. ;

Allen, Judith E. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2013, 210 (11) :2477-2491

[82] A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages [J].

Joshi, Nikita ;

Watanabe, Satoshi ;

Verma, Rohan ;

Jablonski, Renea P. ;

Chen, Ching-I ;

Cheresh, Paul ;

Markov, Nikolay S. ;

Reyfman, Paul A. ;

McQuattie-Pimentel, Alexandra C. ;

Sichizya, Lango ;

Lu, Ziyan ;

Piseaux-Aillon, Raul ;

Kirchenbuechler, David ;

Flozak, Annette S. ;

Gottardi, Cara J. ;

Cuda, Carla M. ;

Perlman, Harris ;

Jain, Manu ;

Kamp, David W. ;

Budinger, G. R. Scott ;

Misharin, Alexander V. .

EUROPEAN RESPIRATORY JOURNAL, 2020, 55 (01)

[83] IL-10-producing lung interstitial macrophages prevent neutrophilic asthma [J].

Kawano, Hideo ;

Kayama, Hisako ;

Nakama, Takekuni ;

Hashimoto, Takashi ;

Umemoto, Eiji ;

Takeda, Kiyoshi .

INTERNATIONAL IMMUNOLOGY, 2016, 28 (10) :489-501

[84] Homeostatic functions of monocytes and interstitial lung macrophages are regulated via collagen domain-binding receptor LAIR1 [J].

Keerthivasan, Shilpa ;

Senbabaoglu, Yasin ;

Martinez-Martin, Nadia ;

Husain, Bushra ;

Verschueren, Erik ;

Wong, Anne ;

Yang, Yeqing Angela ;

Sun, Yonglian ;

Pham, Victoria ;

Hinkle, Trent ;

Oei, Yoko ;

Madireddi, Shravan ;

Corpuz, Racquel ;

Tam, Lucinda ;

Carlisle, Samantha ;

Roose-Girma, Merone ;

Modrusan, Zora ;

Ye, Zhengmao ;

Koerber, James T. ;

Turley, Shannon J. .

IMMUNITY, 2021, 54 (07) :1511-+

[85] Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/macrophage colony-stimulating factor [J].

Kitamura, T ;

Tanaka, N ;

Watanabe, J ;

Uchida, K ;

Kanegasaki, S ;

Yamada, Y ;

Nakata, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (06) :875-880

[86] Integrin β6 mediates phospholipid and collectin homeostasis by activation of latent TGF-β1 [J].

Koth, Laura L. ;

Alex, Byron ;

Hawgood, Samuel ;

Nead, Michael A. ;

Sheppard, Dean ;

Erle, David J. ;

Morris, David G. .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2007, 37 (06) :651-659

[87] Critical Role of Macrophages and Their Activation via MyD88-NFκB Signaling in Lung Innate Immunity to Mycoplasma pneumoniae [J].

Lai, Jen-Feng ;

Zindl, Carlene L. ;

Duffy, Lynn B. ;

Atkinson, T. Prescott ;

Jung, Yong Woo ;

van Rooijen, Nico ;

Waites, Ken B. ;

Krause, Duncan C. ;

Chaplin, David D. .

PLOS ONE, 2010, 5 (12)

[88] Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses [J].

Lavin, Yonit ;

Kobayashi, Soma ;

Leader, Andrew ;

Amir, El-ad David ;

Elefant, Naama ;

Bigenwald, Camille ;

Remark, Romain ;

Sweeney, Robert ;

Becker, Christian D. ;

Levine, Jacob H. ;

Meinhof, Klaus ;

Chow, Andrew ;

Kim-Shulze, Seunghee ;

Wolf, Andrea ;

Medaglia, Chiara ;

Li, Hanjie ;

Rytlewski, Julie A. ;

Emerson, Ryan O. ;

Solovyov, Alexander ;

Greenbaum, Benjamin D. ;

Sanders, Catherine ;

Vignali, Marissa ;

Beasley, Mary Beth ;

Flores, Raja ;

Gnjatic, Sacha ;

Pe'er, Dana ;

Rahman, Adeeb ;

Amit, Ido ;

Merad, Miriam .

CELL, 2017, 169 (04) :750-765

[89] Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment [J].

Lavin, Yonit ;

Winter, Deborah ;

Blecher-Gonen, Ronnie ;

David, Eyal ;

Keren-Shaul, Hadas ;

Merad, Miriam ;

Jung, Steffen ;

Amit, Ido .

CELL, 2014, 159 (06) :1312-1326

[90] Human and Mouse Transcriptome Profiling Identifies Cross-Species Homology in Pulmonary and Lymph Node Mononuclear Phagocytes [J].

Leach, Sonia M. ;

Gibbings, Sophie L. ;

Tewari, Anita D. ;

Atif, Shaikh M. ;

Vestal, Brian ;

Danhorn, Thomas ;

Janssen, William J. ;

Wager, Tor D. ;

Jakubzick, Claudia, V .

CELL REPORTS, 2020, 33 (05)

← 4 5 6 7 8 9 10 11 12 13 →