Estrogen receptor-β inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice

被引：82

作者：

Chagin, AS

Lindberg, MK

Andersson, N

Moverare, S

Gustafsson, JÅ

Sävendahl, L

Ohlsson, C

机构：

[1] Karolinska Inst, Dept Woman & Child Hlth, Pediat Endocrinol Unit, S-10401 Stockholm, Sweden

[2] Sahlgrens Univ Hosp, Div Endocrinol, Dept Internal Med, S-41345 Gothenburg, Sweden

[3] Karolinska Inst, Dept Med Nutr, Stockholm, Sweden

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 01期

关键词：

knockout mice; estrogen; receptor; growth plate; fusion;

D O I：

10.1359/JBMR.0301203

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To determine the long-term role of ERbeta in the regulation of longitudinal bone growth, appendicular and axial skeletal growth was followed and compared in female ERbeta(-/-), ERalpha(-/-), and ERalpha(-/-)beta(-/-) mice. Our results show that ERbeta inhibits appendicular and axial skeletal growth and has the capacity to induce fusion of the growth plates.

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页码：72 / 77

页数：6

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