Estrogen receptor-β inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice

被引：81
作者：
Chagin, AS
Lindberg, MK
Andersson, N
Moverare, S
Gustafsson, JÅ
Sävendahl, L
Ohlsson, C
机构：
[1] Karolinska Inst, Dept Woman & Child Hlth, Pediat Endocrinol Unit, S-10401 Stockholm, Sweden
[2] Sahlgrens Univ Hosp, Div Endocrinol, Dept Internal Med, S-41345 Gothenburg, Sweden
[3] Karolinska Inst, Dept Med Nutr, Stockholm, Sweden
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 01期
关键词：
knockout mice; estrogen; receptor; growth plate; fusion;
D O I：
10.1359/JBMR.0301203
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
To determine the long-term role of ERbeta in the regulation of longitudinal bone growth, appendicular and axial skeletal growth was followed and compared in female ERbeta(-/-), ERalpha(-/-), and ERalpha(-/-)beta(-/-) mice. Our results show that ERbeta inhibits appendicular and axial skeletal growth and has the capacity to induce fusion of the growth plates.
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收藏
页码：72 / 77
页数：6
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