Effects of Resistance Training on Vascular and Hemodynamic Responses in Patients With Coronary Artery Disease

Purpose: The purpose of this study was to determine the impact of adjunctive resistance training (RT) in aerobically trained patients with coronary artery disease on systolic blood pressure (SBP), heart rate (HR), rating of perceived exertion (RPE; using the traditional 6-to-20 scale), and rate-pressure product (RPP) responses to lifting fixed submaximal workloads. Additionally, pretest and posttest RT measures of brachial artery reactivity were obtained. Method: Fifteen patients with coronary artery disease (M-age=66.1 +/- 5.1years) who were already performing regular aerobic exercise completed an adjunctive 12-week progressive RT program. Prior to and immediately after the training period, hemodynamic responses and RPE were obtained while participants performed one set of exercises including the bicep curl (BC), shoulder press (SP), and leg press (LP) at individually determined fixed submaximal loads, using 60% to 80% of estimated maximal voluntary contraction. Vascular function was assessed by flow-mediated vasodilation (FMD) testing before and after training. Results: Attenuated hemodynamic and RPE responses for all variables were observed. Meaningful changes were attained for RPP ([HR x SBP] / 100) during BC (106 +/- 27 mmHg x beats/min x 10(-2) to 91 +/- 22mmHg x beats/min x 10(-2), d=0.6, p<.05) and SP (102 +/- 24 mmHg x beats/min x 10(-2) to 86 +/- 17mmHg x beats/min x 10(-2), d=0.8, p<.05). Rating of perceived exertion decreased significantly during all exercises (d ranging from 1.8 to 3.1, p<.05): BC (14.3 +/- 2.6 to 9.7 +/- 1.6), SP (13.9 +/- 1.6 to 9.2 +/- 1.5), and LP (14.3 +/- 1.4 to 10.3 +/- 1.6). Peak group FMD responses were 12.8% and 10.3% dilation at pretraining and posttraining, respectively (p>.05). Five of the 15 participants showed modest improvements in their posttraining time to achieve maximum dilation from a mean of 117s to 81s, although this change was not statistically significant (p>.05). Conclusion: Among aerobically trained cardiac patients, a supplemental RT program resulted in decreased hemodynamic and RPE responses to lifting fixed submaximal workloads.