Short time exposure to ambient ozone and associated cardiovascular effects: A panel study of healthy young adults

被引：30

作者：

Song, Jie ^{[1
]}

Zhu, Jingfang ^{[1
]}

Tian, Ge ^{[1
]}

Li, Haibin ^{[1
]}

Li, Huijun ^{[1
]}

An, Zhen ^{[1
]}

Jiang, Jing ^{[1
]}

Fan, Wei ^{[1
]}

Wang, Gui ^{[1
]}

Zhang, Yange ^{[1
]}

Wu, Weidong ^{[1
]}

机构：

[1] Xinxiang Med Univ, Sch Publ Hlth, Henan Int Collaborat Lab Hlth Effects & Intervent, Xinxiang 453003, Henan, Peoples R China

来源：

ENVIRONMENT INTERNATIONAL | 2020年 / 137卷

基金：

中国国家自然科学基金;

关键词：

Ozone; Blood pressure; Systemic biomarker; Glutathione S-Transferase; PARTICULATE AIR-POLLUTION; SHORT-TERM EXPOSURE; BLOOD-PRESSURE; OXIDATIVE STRESS; DAILY MORTALITY; DISEASE; INFLAMMATION; TEMPERATURE; MATTER; AGGREGATION;

D O I：

10.1016/j.envint.2020.105579

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The evidence that exposure to ambient ozone (O-3) causes acute cardiovascular effects appears inconsistent. A repeated-measure study with 61 healthy young volunteers was conducted in Xinxiang, Central China. Real-time concentrations of O-3 were monitored. Cardiovascular outcomes including blood pressure (BP), heart rate (HR), serum levels of high sensitivity C-reactive protein (hs-CRP), 8-hydroxy-2'-deoxyguanosine (8-OHdG), tissue-type plasminogen activator (t-PA), and platelet-monocyte aggregation (PMA) were repeated measured. Linear mixed-effect models were used to analyze the association of ambient O-3 with these cardiovascular outcomes. Additionally, the modifying effects of glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1) polymorphisms were estimated to explore the potential mechanisms and role of the association between O-3 exposure and the above cardiovascular outcomes. A 10 mu g/m(3) increase in O-3 was associated with increases of 9.2 mmHg (95% confidence interval [CI]: 2.5, 15.9), 7.2 mmHg (95% CI: 0.8, 13.6), and 21.2 bpm (95% CI: 5.8, 36.6) in diastolic BP (DBP, lag1), mean arterial BP (MABP, lag1), and HR (lag01), respectively. Meanwhile, the serum concentrations of hs-CRP, 8-OHdG, and t-PA were all increased by O-3 exposure, but the PMA level was decreased. Stratification analyses showed that the estimated effects of O-3 on DBP, MABP, and HR in GSTM1-sufficient subjects were significantly higher than in GSTM1-null subjects. Moreover, GSTM1-null genotype enhanced O-3-induced increases, albeit insignificant, in levels of serum hs-CRP, 8-OHdG, and t-PA compared with GSTM1-sufficient genotype. Insignificant increases in hs-CRP and t-PA were also detected in GSTT1-null subjects. Taken together, our findings indicate that acute exposure to ambient O-3 induces autonomic alterations, systemic inflammation, oxidative stress, and fibrinolysis in healthy young subjects. GSTM1 genotype presents the trend of modifying O-3-induced cardiovascular effects.

引用

页数：8

共 54 条

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