Study on bio-corrosion and cytotoxicity of a sr-based bulk metallic glass as potential biodegradable metal

被引:22
作者
Li, H. F. [1 ,2 ]
Zhao, K. [3 ]
Wang, Y. B. [1 ,2 ]
Zheng, Y. F. [1 ,2 ]
Wang, W. H. [3 ]
机构
[1] Peking Univ, Coll Engn, State Key Lab Turbulence & Complex Syst, Beijing 100871, Peoples R China
[2] Peking Univ, Coll Engn, Dept Adv Mat & Nanotechnol, Beijing 100871, Peoples R China
[3] Chinese Acad Sci, Inst Phys, Beijing 100190, Peoples R China
基金
中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词
Sr-based bulk metallic glasses; mechanical property; corrosion behavior; cytotoxicity; REBALANCING BONE TURNOVER; STRONTIUM SALT S12911; HA BIOACTIVE CEMENT; DUAL-MODE; IN-VITRO; MAGNESIUM ALLOYS; TISSUE-CULTURE; GROWING RATS; ZR ADDITIONS; RESISTANCE;
D O I
10.1002/jbm.b.31958
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
In this study, a novel Sr-based bulk metallic glass (BMG) with nominal composition of Sr40Mg20Zn15Yb20Cu5 (at.%) was fabricated with high-purity raw materials by induction-melting method. Its mechanical properties, corrosion behavior, and cellular compatibility were studied in vitro as a feasibility evaluation of potential biodegradable metal. The compression strength of Sr40Mg20Zn15Yb20Cu5 alloy was (408.2 +/- 20.0) MPa, which was much higher than human bone (164240 MPa). Its Young's modulus (20.6 +/- 0.2) GPa was quite close to human bone (523 GPa). MTT assay and PNPP method were employed to measure the proliferation ability and ALP activity of the experimental Sr-based BMG. The results 01 grade cytotoxicity and high ALP activity revealed that it was harmless to osteoblast-like MG63 cells. Additionally, the cells cultured on the surface of Sr40Mg20Zn15Yb20Cu5 alloy plate exhibited polygonal and dorsal ruffle configuration, and were well attached to the substrate by cellular extension, indicating their healthy status. The combination of increased mechanical strength, greater corrosion resistance, and excellent biocompatibility makes the Sr40Mg20Zn15Yb20Cu5 BMG very attractive material for biodegradable orthopedic implant applications. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 100B: 368377, 2012.
引用
收藏
页码:368 / 377
页数:10
相关论文
共 63 条
[1]   Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats [J].
Ammann, P ;
Shen, V ;
Robin, B ;
Mauras, Y ;
Bonjour, JP ;
Rizzoli, R .
JOURNAL OF BONE AND MINERAL RESEARCH, 2004, 19 (12) :2012-2020
[2]   Strontium ranelate: A novel mode of action leading to renewed bone quality [J].
Ammann, P .
OSTEOPOROSIS INTERNATIONAL, 2005, 16 (Suppl 1) :S11-S15
[3]  
ARLOT ME, 1995, J BONE MINER RES, V10, pS356
[4]   Strontium-substituted hydroxyapatite nanocrystals [J].
Bigi, Adriana ;
Boanini, Elisa ;
Capuccini, Chiara ;
Gazzano, Massimo .
INORGANICA CHIMICA ACTA, 2007, 360 (03) :1009-1016
[5]   SR-89 THERAPY - STRONTIUM KINETICS IN DISSEMINATED CARCINOMA OF THE PROSTATE [J].
BLAKE, GM ;
ZIVANOVIC, MA ;
MCEWAN, AJ ;
ACKERY, DM .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1986, 12 (09) :447-454
[6]   The antibacterial effects of zinc ion migration from zinc-based glass polyalkenoate cements [J].
Boyd, D. ;
Li, H. ;
Tanner, D. A. ;
Towler, M. R. ;
Wall, J. G. .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2006, 17 (06) :489-494
[7]   The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro [J].
Canalis, E ;
Hott, M ;
Deloffre, P ;
Tsouderos, Y ;
Marie, PJ .
BONE, 1996, 18 (06) :517-523
[8]   Effect of surface chemistries and characteristics of Ti6Al4V on the Ca and P adsorption and ion dissolution in Hank's ethylene diamine tetra-acetic acid solution [J].
Chang, E ;
Lee, TM .
BIOMATERIALS, 2002, 23 (14) :2917-2925
[9]   Expression and signal transduction of calcium-sensing receptors in cartilage and bone [J].
Chang, YH ;
Tu, CL ;
Chen, TH ;
Komuves, L ;
Oda, Y ;
Pratt, SA ;
Miller, S ;
Shoback, D .
ENDOCRINOLOGY, 1999, 140 (12) :5883-5893
[10]   Effect of of Yb, Cr and Zr additions on recrystallization and corrosion resistance of Al-Zn-Mg-Cu alloys [J].
Chen, K. H. ;
Fang, H. C. ;
Zhang, Z. ;
Chen, X. ;
Liu, G. .
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING, 2008, 497 (1-2) :426-431