New cytotoxic oxygenated sterols from marine bryozoan Bugula neritina

被引：4
作者：
Yang, Fan [1 ]
Zhang, Hong-Jun [1 ]
Chen, Jian-Tao [1 ]
Tang, Hai-Feng [2 ]
Piao, Shu-Juan [1 ]
Chen, Wan-Sheng [1 ]
Lin, Hou-Wen [1 ]
机构：
[1] Second Mil Med Univ, Changzheng Hosp, Lab Marine Drugs, Dept Pharm, Shanghai 200003, Peoples R China
[2] Fourth Mil Med Univ, Xijing Hosp, Dept Pharm, Xian 710032, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2011年 / 25卷 / 16期
基金：
国家高技术研究发展计划(863计划);
关键词：
marine bryozoan; Bugula neritina; steroid; cytotoxicity; ANTINEOPLASTIC AGENTS;
D O I：
10.1080/14786410903211235
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Two new oxygenated sterols, 3 beta,24(S)-dihydroxycholesta-5,25-dien-7-one (1) and 3 beta,25-dihydroxycholesta-5,23-dien-7-one (2), were isolated from the marine bryozoan Bugula neritina. Their chemical structures were established on the basis of spectroscopic analysis. Both compounds exhibited cytotoxicity to three human cancer cell lines (HepG2, HT-29 and NCI-H460), with IC50 values between 22.58 and 53.41 mu g mL(-1).
引用
收藏
页码：1505 / 1511
页数：7
相关论文
共 24 条
  • [1] STEROLS FROM MARINE GREEN-ALGA CODIUM-DECORTICATUM
    AHMAD, VU
    ALIYA, R
    PERVEEN, S
    SHAMEEL, M
    [J]. PHYTOCHEMISTRY, 1993, 33 (05) : 1189 - 1192
  • [2] SECONDARY METABOLITES FROM MARINE BRYOZOANS - A REVIEW
    CHRISTOPHERSEN, C
    [J]. ACTA CHEMICA SCANDINAVICA SERIES B-ORGANIC CHEMISTRY AND BIOCHEMISTRY, 1985, 39 (07): : 517 - 529
  • [3] Faulkner DJ, 1998, NAT PROD REP, V15, P113
  • [4] Identification and biosynthetic origins of sterols in the marine bryozoan Bugula neritina
    Kerr, RG
    Vicchiarelli, R
    Kerr, SS
    [J]. JOURNAL OF NATURAL PRODUCTS, 1999, 62 (03): : 468 - 470
  • [5] Structure of bryostatin 20:: A symbiont-produced chemical Defense for larvae of the host bryozoan, Bugula neritina
    Lopanik, N
    Gustafson, KR
    Lindquist, N
    [J]. JOURNAL OF NATURAL PRODUCTS, 2004, 67 (08): : 1412 - 1414
  • [6] Cytotoxic hydroxylated triterpene alcohol ferulates from rice bran
    Luo, HF
    Li, QL
    Yu, SG
    Badger, TM
    Fang, NB
    [J]. JOURNAL OF NATURAL PRODUCTS, 2005, 68 (01): : 94 - 97
  • [7] Pettit G R, 1991, Fortschr Chem Org Naturst, V57, P153
  • [8] ANTINEOPLASTIC AGENTS .118. ISOLATION AND STRUCTURE OF BRYOSTATIN-9
    PETTIT, GR
    KAMANO, Y
    HERALD, CL
    [J]. JOURNAL OF NATURAL PRODUCTS, 1986, 49 (04): : 661 - 664
  • [9] ANTINEOPLASTIC AGENTS .224. ISOLATION AND STRUCTURE OF NERISTATIN-1
    PETTIT, GR
    GAO, F
    HERALD, DL
    BLUMBERG, PM
    LEWIN, NE
    NIEMAN, RA
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (17) : 6693 - 6695
  • [10] ANTI-NEOPLASTIC AGENTS .89. THE STRUCTURE OF BRYOSTATIN-2 FROM THE MARINE BRYOZOAN BUGULA-NERITINA
    PETTIT, GR
    HERALD, CL
    KAMANO, Y
    GUST, D
    AOYAGI, R
    [J]. JOURNAL OF NATURAL PRODUCTS, 1983, 46 (04): : 528 - 531
123