New cytotoxic oxygenated sterols from marine bryozoan Bugula neritina

被引:4
作者
Yang, Fan [1 ]
Zhang, Hong-Jun [1 ]
Chen, Jian-Tao [1 ]
Tang, Hai-Feng [2 ]
Piao, Shu-Juan [1 ]
Chen, Wan-Sheng [1 ]
Lin, Hou-Wen [1 ]
机构
[1] Second Mil Med Univ, Changzheng Hosp, Lab Marine Drugs, Dept Pharm, Shanghai 200003, Peoples R China
[2] Fourth Mil Med Univ, Xijing Hosp, Dept Pharm, Xian 710032, Peoples R China
基金
国家高技术研究发展计划(863计划);
关键词
marine bryozoan; Bugula neritina; steroid; cytotoxicity; ANTINEOPLASTIC AGENTS;
D O I
10.1080/14786410903211235
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Two new oxygenated sterols, 3 beta,24(S)-dihydroxycholesta-5,25-dien-7-one (1) and 3 beta,25-dihydroxycholesta-5,23-dien-7-one (2), were isolated from the marine bryozoan Bugula neritina. Their chemical structures were established on the basis of spectroscopic analysis. Both compounds exhibited cytotoxicity to three human cancer cell lines (HepG2, HT-29 and NCI-H460), with IC50 values between 22.58 and 53.41 mu g mL(-1).
引用
收藏
页码:1505 / 1511
页数:7
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