Reduced cortical thickness in right Heschl's gyrus associated with auditory verbal hallucinations severity in first-episode schizophrenia

被引：43

作者：

Chen, Xudong ^{[1
]}

Liang, Shengxiang ^{[2
]}

Pu, Weidan ^{[3
]}

Song, Yinnan ^{[2
]}

Mwansisya, Tumbwene E. ^{[1
,4
]}

Yang, Qing ^{[5
]}

Liu, Haihong ^{[6
]}

Liu, Zhening ^{[1
]}

Shan, Baoci ^{[2
]}

Xue, Zhimin ^{[1
]}

机构：

[1] Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Key Lab Psychiat & Mental Hlth Hunan Prov, Changsha 410011, Hunan, Peoples R China

[2] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Anal Tech, Beijing, Peoples R China

[3] Cent S Univ, Xiangya Hosp 2, Inst Med Psychol, Changsha 410011, Hunan, Peoples R China

[4] Univ Dodoma, Dept Clin Nursing & Community Hlth, Dodoma, Tanzania

[5] Yale Univ, Sch Med, Dept Med, Yale New Haven Hosp, New Haven, CT 06510 USA

[6] Cent S Univ, Xiangya Hosp, Mental Hlth Ctr, Changsha 410011, Hunan, Peoples R China

来源：

BMC PSYCHIATRY | 2015年 / 15卷

关键词：

Schizophrenia; Auditory hallucination; Cortical thickness; Magnetic resonance imaging; Heschl's gyrus; 1ST EPISODE SCHIZOPHRENIA; PROGRESSIVE BRAIN CHANGES; HUMAN CEREBRAL-CORTEX; MATTER VOLUME; METAANALYSIS; MORPHOMETRY; ANTIPSYCHOTICS; ABNORMALITIES; NEUROANATOMY; HYPOTHESIS;

D O I：

10.1186/s12888-015-0546-2

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: Auditory verbal hallucinations (AVHs) represent one of the most intriguing phenomena in schizophrenia, however, brain abnormalities underlying AVHs remain unclear. The present study examined the association between cortical thickness and AVHs in first-episode schizophrenia. Method: High-resolution MR images were obtained in 49 first-episode schizophrenia (FES) patients and 50 well-matched healthy controls (HCs). Among the FES patients, 18 suffered persistent AVHs ("auditory hallucination" AH group), and 31 never experienced AVHs ("no hallucination" NH group). The severity of AVHs was rated by the Auditory Hallucinations Rating Scale (AHRS). Cortical thickness differences among the three groups and their association with AVHs severity were examined. Results: Compared to both HCs and NH patients, AH patients showed lower cortical thickness in the right Heschl's gyrus. The degree of reduction in the cortical thickness was correlated with AVH severity in the AH patients. Conclusions: Abnormalities of cortical thickness in the Heschl's gyrus may be a physiological factor underlying auditory verbal hallucinations in schizophrenia.

引用

页数：8

共 49 条

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