A short history of the B-cell-associated surface molecule CD40

被引：19

作者：

Clark, Edward A. ^{[1
]}

机构：

[1] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2014年 / 5卷

关键词：

B cell; CD40; monoclonal antibody; activation; therapy; ANTI-CD40; MONOCLONAL-ANTIBODY; HUMAN DENDRITIC CELLS; GROWTH-FACTOR; LYMPHOCYTE ACTIVATION; SIGNAL-TRANSDUCTION; ANTIGEN; PROLIFERATION; INDUCTION; SYNERGISM; CANCER;

D O I：

10.3389/fimmu.2014.00472

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This perspective traces developments using monoclonal antibody technology that led to the discovery of CD40, a receptor that on B cells mediates "T cell help" and on dendritic cells helps to program CD8T cell responses. I discuss some things that we got right during the path of discovery and some things we missed. Immunotherapies that block or stimulate the CD40 pathway hold great promise for treatment of autoimmune diseases and cancers.

引用

页数：5

共 53 条

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