Rational Chemical Multifunctionalization of Graphene Interface Enhances Targeted Cancer Therapy

被引：26

作者：

Lucherelli, Matteo Andrea ^{[1
]}

Yu, Yue ^{[2
,4
]}

Reina, Giacomo ^{[1
]}

Abellan, Gonzalo ^{[3
]}

Miyako, Eijiro ^{[2
]}

Bianco, Alberto ^{[1
]}

机构：

[1] Univ Strasbourg, CNRS, UPR 3572, Immunol Immunopathol & Therapeut Chem,ISIS, F-67000 Strasbourg, France

[2] Japan Adv Inst Sci & Technol, Grad Sch Adv Sci & Technol, 1-1 Asahidai, Nomi, Ishikawa 9231292, Japan

[3] Univers Valencia, Inst Ciencia Mol ICMol, Catedrat Jose Beltran 2, Valencia 46980, Spain

[4] Natl Inst Adv Ind Sci & Technol, Biomed Res Inst, Ikeda, Osaka 5638577, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2020年 / 59卷 / 33期

基金：

日本学术振兴会;

关键词：

cancer therapy; carbon materials; diazonium salts; graphite; multifunctionalization; OXIDE; ACCUMULATION;

D O I：

10.1002/anie.201916112

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of a drug delivery platform based on graphene was achieved through a step-by-step strategy of selective amine deprotection and functionalization. The multifunctional graphene platform, functionalized with indocyanine green, folic acid, and doxorubicin showed an enhanced anticancer activity. The remarkable targeting capacity for cancer cells in combination with the synergistic effect of drug release and photothermal properties prove the great advantage of a combined chemo- and phototherapy based on graphene against cancer, opening the doors to future therapeutic applications of this type of material.

引用

收藏

页码：14034 / 14039

页数：6

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