Synthesis and Characterization of a Dinuclear Copper Complex Bearing a Hydrophobic Cavity as a Model for Copper-Containing Monooxygenases

被引：0

作者：

Schicke, Olivier ^{[1
]}

Faure, Bruno ^{[1
]}

Carissan, Yannick ^{[1
]}

Giorgi, Michel ^{[2
]}

Simaan, Ariane Jalila ^{[1
]}

Reglier, Marius ^{[1
]}

机构：

[1] Aix Marseille Univ, Cent Marseille, CNRS, UMR ISM2 7313, F-13397 Marseille, France

[2] Aix Marseille Univ, Spectropole, CNRS, FR1739, F-13397 Marseille, France

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2015年 / 21期

关键词：

Host-guest systems; Enzyme models; Cyclophanes; Copper; CONCAVE FUNCTIONALITY; REACTIVITY; OXIDATION; RECEPTOR; DESIGN;

D O I：

10.1002/ejic.201500280

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis and characterization of a dinuclear copper complex as a model of mononuclear copper-containing monooxygenases [dopamine beta-monooxygenase (D beta M), tyramine beta-monooxygenase (T beta M), and peptidylglycine alpha-hydroxylating monooxygenase (PHM)] are described. This model is based on a cyclophane moiety bearing two bis-(picolylamine) ligands for the complexation of two copper atoms and exhibits macroscopic features equivalent to those of the enzymes: (1) the two copper centers are 11.5 angstrom ap(11 angstrom for the enzymes) and (2) there is a hydrophobic pocket consisting of a cyclophane moiety in which substrates can bind near the two copper centers.

引用

页码：3512 / 3518

页数：7

共 38 条

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