Immunovirological outcome and HIV-1 DNA decay in a small cohort of HIV-1-infected patients deintensificated from Abacavir/Lamivudine/Dolutegravir to Lamivudine plus Dolutegravir

被引:0
作者
Lanzafame, Massimiliano [1 ]
Nicole, Stefano [2 ]
Rizzardo, Sebastian [2 ]
Piacentini, Daniela [2 ]
Chiesi, Sheila [2 ]
Lattuada, Emanuela [2 ]
Diani, Erica [3 ]
Carelli, Maria [3 ]
Vento, Sandro [4 ,5 ]
Gibellini, Davide [3 ]
机构
[1] Univ Verona, Unita Semplice Organizzat Diagnosi & Terapia Infe, Verona, Italy
[2] Univ Verona, Unita Complessa Malattie Infett, Verona, Italy
[3] Univ Verona, Dept Diagnost & Publ Hlth, Microbiol & Virol Sect, Verona, Italy
[4] Nazarbayev Univ, Dept Med, Astana, Kazakhstan
[5] Univ Med Ctr, Astana, Kazakhstan
关键词
Abacavir/lamivudine/dolutegravir; Deintensification; HIV DNA decay; HAART; DIAGNOSTIC-CLINICAL MANAGEMENT; ONCE-DAILY DOLUTEGRAVIR; ANTIRETROVIRAL THERAPY; INFECTED PATIENTS; PROTEASE INHIBITOR; ITALIAN GUIDELINES; TRIPLE THERAPY; NAIVE ADULTS; OPEN-LABEL; RALTEGRAVIR;
D O I
暂无
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Combination abacavir/lamivudine/dolutegravir (ABC/3TC/DTG) is approved as a first-line treatment for antiretroviral naive patients. This report investigated the immunovirological outcome and total HIV-1 DNA decay in a small cohort of nave HIV-1-positive patients treated with this regimen. In the presence of viral suppression and increased lymphocyte T CD4+ cells, the quantitative analysis of total HIV-1 DNA content revealed a significant decay after 12 months of treatment. Subsequently, we deintensificated the treatment of these patients from (ABC/3TC/DTG) to lamivudine plus dolutegravir (3TC/DTG) after 12 months of virological suppression, as a strategy of "induction-maintenance" therapy. The analysis of HIV-1 RNA viral load, total HIV-1 DNA, CD4+ T lymphocyte count and CD8+HLA-DR+ T lymphocyte percentage after a mean 3.5 months of therapy deintensification showed no significant difference with respect to data detected after 12 months of ABC/3TC/DTG treatment in the presence of continuous viral suppression. These results indicate that the deintensification of highly active antiretroviral therapy (HAART) from ABC/3TC/DTG to 3TC/DTG effectively controls HIV-1 replication and in the early period does not induce any significant variations of total HIV-1 DNA. This suggests that HAART deintensification might be proposed as a therapeutic evolution in the treatment of HIV-1 infection.
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页码:262 / 267
页数:6
相关论文
共 45 条
[1]  
Amendola A, 2017, NEW MICROBIOL, V40, P234
[2]   HIV drug resistance against strand transfer integrase inhibitors [J].
Anstett, Kaitlin ;
Brenner, Bluma ;
Mesplede, Thibault ;
Wainberg, Mark A. .
RETROVIROLOGY, 2017, 14
[3]  
Antinori A, 2017, NEW MICROBIOL, V40, P86
[4]  
Antinori A, 2016, NEW MICROBIOL, V39, P93
[5]   Efficacy of protease inhibitor monotherapy vs. triple therapy: meta-analysis of data from 2303 patients in 13 randomized trials [J].
Arribas, J. R. ;
Girard, P-M ;
Paton, N. ;
Winston, A. ;
Marcelin, A-G ;
Elbirt, D. ;
Hill, A. ;
Hadacek, M. B. .
HIV MEDICINE, 2016, 17 (05) :358-367
[6]   Total HIV-1 DNA, a Marker of Viral Reservoir Dynamics with Clinical Implications [J].
Avettand-Fenoel, Veronique ;
Hocqueloux, Laurent ;
Ghosn, Jade ;
Cheret, Antoine ;
Frange, Pierre ;
Melard, Adeline ;
Viard, Jean-Paul ;
Rouzioux, Christine .
CLINICAL MICROBIOLOGY REVIEWS, 2016, 29 (04) :859-880
[7]   Impact of 48 week lopinavir/ritonavir monotherapy on blood cell-associated HIV-1-DNA in the MONARK trial [J].
Avettand-Fenoel, Veronique ;
Flandre, Philippe ;
Chaix, Marie-Laure ;
Ghosn, Jade ;
Delaugerre, Constance ;
Raffi, Francois ;
NgoVan, Philippe ;
Cohen-Codar, Isabelle ;
Delfraissy, Jean-Francois ;
Rouzioux, Christine .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2010, 65 (05) :1005-1007
[8]   Metabolic bone disease in HIV infection [J].
Borderi, Marco ;
Gibellini, Davide ;
Vescini, Fabio ;
De Crignis, Elisa ;
Cimatti, Laura ;
Biagetti, Carlo ;
Tampellini, Livia ;
Re, Maria C. .
AIDS, 2009, 23 (11) :1297-1310
[9]   Dolutegravir Dual Therapy as Maintenance Treatment in HIV-Infected Patients: A Review [J].
Boswell, Rosaleen ;
Foisy, Michelle M. ;
Hughes, Christine A. .
ANNALS OF PHARMACOTHERAPY, 2018, 52 (07) :681-689
[10]   HIV-1 DNA concentrations and evolution among African HIV-1-infected children under antiretroviral treatment (ANRS 1244/1278) [J].
Boulle, Charlotte ;
Rouet, Francois ;
Fassinou, Patricia ;
Msellati, Philippe ;
Debeaudrap, Pierre ;
Chaix, Marie-Laure ;
Rouzioux, Christine ;
Avettand-Fenoel, Ronique .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2014, 69 (11) :3047-3050