Betablockers at work:: The crystal structure of the β2-adrenergic receptor

被引：10

作者：

Hausch, Felix ^{[1
]}

机构：

[1] Max Planck Inst Psychiat, D-80804 Munich, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 18期

关键词：

betablockers; medicinal chemistry; membrane proteins; protein structures; receptors;

D O I：

10.1002/anie.200705971

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Rational drug design is still limited for many membrane proteins. For the β2-adrenergic receptor, a prototype of the class A GPCR family, structures with up to 2.4-Å resolution have now been solved. The structure (see figure) shows detailed contacts of the receptor (green) with its ligand carazolol (pink), and makes possible the formulation of hypotheses for the mode of action of G-protein-coupled receptors. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：3314 / 3316

页数：3

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