Revisiting the Rule of Five on the Basis of Pharmacokinetic Data from Rat

被引：8

作者：

Ridder, Lars ^{[1
]}

Wang, Hongwu ^{[2
]}

de Vlieg, Jacob ^{[1
,3
]}

Wagener, Markus ^{[1
]}

机构：

[1] Merck Res Labs, NL-5342 CC Oss, Netherlands

[2] Merck Res Labs, Kenilworth, NJ 07033 USA

[3] Radboud Univ Nijmegen, Med Ctr, Ctr Mol & Biomol Informat, NL-6525 GA Nijmegen, Netherlands

来源：

CHEMMEDCHEM | 2011年 / 6卷 / 11期

关键词：

LMW gonadotropins; oral absorption; physicochemical properties; rat pharmacokinetics; Rule of Five; MOLECULAR-WEIGHT AGONIST; ORAL BIOAVAILABILITY; DRUG DISCOVERY; PREDICTION; ABSORPTION; TRANSPORT; OVULATION; SURFACE; HUMANS; POTENT;

D O I：

10.1002/cmdc.201100306

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：1967 / 1970

页数：4

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