Current Status of Staphylococcal Cassette Chromosome mec (SCCmec)

被引：74

作者：

Uehara, Yuki ^{[1
,2
,3
,4
]}

机构：

[1] Juntendo Univ, Dept Microbiol, Fac Med, Tokyo 1130033, Japan

[2] Juntendo Univ, Dept Gen Med, Fac Med, Tokyo 1130033, Japan

[3] St Lukes Int Hosp, Dept Clin Lab, Tokyo 1048560, Japan

[4] St Lukes Int Hosp, Dept Infect Dis, Tokyo 1048560, Japan

来源：

ANTIBIOTICS-BASEL | 2022年 / 11卷 / 01期

关键词：

methicillin-resistant Staphylococcus aureus; staphylococcal cassette chromosome mec (SCCmec); SCCmec typing; SCCmec subtyping; International Working Group on the Classification of Staphylococcal Cassette Chromosome Elements; PENICILLIN-BINDING PROTEIN; NUCLEOTIDE-SEQUENCE DETERMINATION; MULTIPLEX PCR ASSAY; METHICILLIN-RESISTANT; MOLECULAR-CLONING; GENETIC DIVERSITY; AUREUS; INFECTIONS; COMMUNITY; CLONES;

D O I：

10.3390/antibiotics11010086

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Staphylococcal cassette chromosome mec (SCCmec) typing was established in the 2000s and has been employed as a tool for the molecular epidemiology of methicillin-resistant Staphylococcus aureus, as well as the evolution investigation of Staphylococcus species. Molecular cloning and the conventional sequencing of SCCmec have been adopted to verify the presence and structure of a novel SCCmec type, while convenient PCR-based SCCmec identification methods have been used in practical settings for many years. In addition, whole-genome sequencing has been widely used, and various SCCmec and similar structures have been recently identified in various species. The current status of the SCCmec types, SCCmec subtypes, rules for nomenclature, and multiple methods for identifying SCCmec types and subtypes were summarized in this review, according to the perspective of the International Working Group on the Classification of Staphylococcal Cassette Chromosome Elements.

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页数：12

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