In this article, supercritical extraction of nimbin from neem seeds has been studied. In order to investigate the effect of parameters on nimbin extraction yield, a partial differential equation model based on mass conservation principles. The model was solved using MATLAB software. The results were successfully validated with available laboratory experimental data. The optimum values of the operating parameters were obtained using gradient search strategy. Optimization routine was employed to maximize process profit. The optimum value of temperature, pressure, CO2 flow rate and particle diameter were found to be 305K, 177.339 bar, 0.9660 cm3/min and 0.0575 cm, respectively. Finally, a sensitivity analysis was carried out on the different model parameters, and found that process profit is mostly sensitive to neem price.
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页码:2156 / 2176
页数:21
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