Stereochemical control of tertiary alcohol: aldol condensation of lactate derivatives

被引：19

作者：

Kamino, T ^{[1
]}

Murata, Y ^{[1
]}

Kawai, N ^{[1
]}

Hosokawa, S ^{[1
]}

Kobayashi, S ^{[1
]}

机构：

[1] Sci Univ Tokyo, Fac Pharmaceut Sci, Shinjuku Ku, Tokyo 1620826, Japan

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 31期

关键词：

D O I：

10.1016/S0040-4039(01)00818-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereoselective construction of aldol adducts having tertiary alcohol at the a position was achieved via a titanium(IV) enolate derived from a lactate derivative with an Evans chiral auxiliary. The stereochemistry at ct-tertiary alcohol could be controlled by selecting the protective group of the starting lactate. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：5249 / 5252

页数：4

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