Influence of Natural Polyphenols on Isolated Yeast Dipodascus magnusii Mitochondria

被引：5

作者：

Dergacheva, D. I. ^{[1
]}

Klein, O. I. ^{[1
]}

Gessler, N. N. ^{[1
]}

Isakova, E. P. ^{[1
]}

Deryabina, Y. I. ^{[1
]}

Nikolaev, A. V. ^{[2
]}

机构：

[1] Russian Acad Sci, Bach Inst Biochem, Fed Res Ctr Fundamental Principles Biotechnol, Moscow, Russia

[2] Russian Acad Sci, Schmidt Inst Phys Earth, Moscow, Russia

来源：

DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2020年 / 490卷 / 01期

关键词：

polyphenols; resveratrol; pinosilvin; dihydromyretin; antioxidant effect; mitochondria; OXIDATIVE STRESS; RESVERATROL; DYSFUNCTION; BIOGENESIS; CELLS;

D O I：

10.1134/S1607672920010044

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of stilbene polyphenols (resveratrol and pinosilvin) and flavonoids (dihydromyricetin, epigallocatechin, and dihydroquercetin) on producing the reactive oxygen species (ROS) due to cell respiration using the isolated mitochondria of the fungus Dipodascus (Endomyces) magnusii was studied. It was shown that the inhibition of the ROS generation with stilbenes is related to both the oxygen consumption inhibition and their antioxidant properties. The degree of manifestation of polyphenol antioxidant properties depended on the number of hydroxyl groups in a polyphenol molecule. Of the flavonoids tested, dihydromyricetin was most active in reducing the ROS generation, but its inhibitory effect on oxygen consumption by mitochondria was significantly lower as compared to that of the stilbenes. The data obtained show that the mechanism of reducing the ROS generation with polyphenols is associated with both the respiratory inhibition and their antioxidant properties.

引用

页码：12 / 15

页数：4

共 15 条

[1] Exposure to resveratrol triggers pharmacological correction of fatty acid utilization in human fatty acid oxidation-deficient fibroblasts [J].

Bastin, Jean ;

Lopes-Costa, Alexandra ;

Djouadi, Fatima .

HUMAN MOLECULAR GENETICS, 2011, 20 (10) :2048-2057

[2] Myricitrin alleviates MPP+-induced mitochondrial dysfunction in a DJ-1-dependent manner in SN4741 cells [J].

Cai, Zhibiao ;

Zeng, Weijun ;

Tao, Kai ;

Lu, Fangfang ;

Gao, Guodong ;

Yang, Qian .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 458 (02) :227-233

[3] Polyphenol compounds and PKC signaling [J].

Das, Joydip ;

Ramani, Rashmi ;

Suraju, M. Olufemi .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2016, 1860 (10) :2107-2121

[4] ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases [J].

Davalli, Pierpaola ;

Mitic, Tijana ;

Caporali, Andrea ;

Lauriola, Angela ;

D'Arca, Domenico .

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2016, 2016

[5] Resveratrol and the mitochondria: From triggering the intrinsic apoptotic pathway to inducing mitochondrial biogenesis, a mechanistic view [J].

de Oliveira, Marcos Roberto ;

Nabavi, Seyed Fazel ;

Manayi, Azadeh ;

Daglia, Maria ;

Hajheydari, Zohreh ;

Nabavi, Seyed Mohammad .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2016, 1860 (04) :727-745

[6] Inhibition of free radical scavenging enzymes affects mitochondrial membrane permeability transition during growth and aging of yeast cells [J].

Deryabina, Yulia ;

Isakova, Elena ;

Sekova, Varvara ;

Antipov, Alexey ;

Saris, Nils-Erik L. .

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 2014, 46 (06) :479-492

[7] Resveratrol Induces a Mitochondrial Complex I-dependent Increase in NADH Oxidation Responsible for Sirtuin Activation in Liver Cells [J].

Desquiret-Dumas, Valerie ;

Gueguen, Naig ;

Leman, Geraldine ;

Baron, Stephanie ;

Nivet-Antoine, Valerie ;

Chupin, Stephanie ;

Chevrollier, Arnaud ;

Vessieres, Emilie ;

Ayer, Audrey ;

Ferre, Marc ;

Bonneau, Dominique ;

Henrion, Daniel ;

Reynier, Pascal ;

Procaccio, Vincent .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (51) :36662-36675

[8] Dihydromyricetin protects endothelial cells from hydrogen peroxide-induced oxidative stress damage by regulating mitochondrial pathways [J].

Hou, Xiaolong ;

Tong, Qing ;

Wang, Wenqing ;

Xiong, Wei ;

Shi, Chunyang ;

Fang, Jianguo .

LIFE SCIENCES, 2015, 130 :38-46

[9] Hesperidin attenuates mitochondrial dysfunction during benzo(a)pyrene-induced lung carcinogenesis in mice [J].

Kamaraj, Sattu ;

Anandakumar, Pandi ;

Jagan, Sundaram ;

Ramakrishnan, Gopalakrishnan ;

Devaki, Thiruvengadam .

FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2011, 25 (01) :91-98

[10] Resveratrol Inhibition of Cellular Respiration: New Paradigm for an Old Mechanism [J].

Madrigal-Perez, Luis Alberto ;

Ramos-Gomez, Minerva .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (03)

← 1 2 →